功能性消化不良患者白细胞介素-6水平与焦虑、抑郁相关性的Meta分析  

Meta-analysis of the Correlation between IL-6 level and Anxiety-Depression in Patients with Functional Dyspepsia

作　　者：代欣玥 李艳玲[1] 张菀桐 杨静[1] 任星 刘艳飞[1] 陆芳[1] 杨巧宁[1] 高蕊[1] DAI Xinyue;LI Yanling;ZHANG Wantong;YANG Jing;REN Xing;LIU Yanfei;LU Fang;YANG Qiaoning;GAO Rui(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《世界中医药》2020年第22期3418-3423,共6页World Chinese Medicine

基　　金：重大新药创制国家重大科技专项(2017ZX09304003)——体现中药特点的重大疾病新药临床评价技术平台建设;“十三五”国家重点研发计划中医药现代化研究专项(2017YFC1703703)——“面向‘一带一路’国家的中医药国际合作示范研究”项目枳术宽中胶囊国际临床研究。

摘　　要：目的:采用Meta分析的方法,评价基于Pearson相关系数的功能性消化不良(FD)患者白细胞介素-6(IL-6)水平与焦虑、抑郁的相关性。方法:分别在PubMed、The cochrane、EMbase、知网、CBM、维普和万方数据库中用计算机检索有关于功能性消化不良患者IL-6水平和焦虑、抑郁相关性的病例对照研究,检索的时间均从建库开始截止至2019年12月。对检索后的文献进行查重、筛选、资料提取并评估纳入研究的偏倚风险,整个过程由2位研究者独立完成,并进行交叉核对,最后Meta分析通过RevMan 5.3软件来完成。结果:最终纳入6个研究,方法学质量中等偏高。Meta分析结果显示,功能性消化不良患者IL-6水平与焦虑具有强正相关性,差异有统计学意义[summary r=0.72,95%CI(0.65,0.77),P<0.00001];功能性消化不良患者IL-6水平与抑郁具有极强正相关性,有统计学意义[summary r=0.83,95%CI(0.66,0.92),P<0.00001],亚组分析结果显示:HAMD量表组:功能性消化不良患者IL-6水平与抑郁具有极强正相关性,差异有统计学意义[summary r=0.91,95%CI(0.18,0.99),P<0.00001],SDS量表组:功能性消化不良患者IL-6水平与抑郁具有强正相关性,差异有统计学意义[summary r=0.78,95%CI(0.64,0.87),P<0.00001]。敏感性分析显示结果稳定。结论:功能性消化不良患者IL-6水平与焦虑、抑郁具有强正相关性。但上述结论的可信性和科学性受到纳入研究数量和质量限制,存在有一定的局限性,故仍需开展更多的高质量、大样本原始研究以期进一步验证。Objective:To evaluate the correlation between interleukin-6(IL-6)levels and anxiety-depression in patients with functional dyspepsia(FD)based on Pearson correlation coefficient(Pearson correlation coefficient)using a meta-analysis.Methods:Controlled trails on the correlation between IL-6 level and anxiety-depression in patients with functional dyspepsia were retrieved by computer in PubMed,The Cochrane,EMbase,CNKI,CBM,VIP and Wanfang databases respectively.The retrieval time was from The beginning of database construction to December 2019.The retrieved literature was duplicate checked,screened,data extracted,and the bias risk of included studies was assessed.The whole process was completed by two researchers independently and cross-checked.Finally,the Meta analysis was completed by RevMan 5.3 software.Results:Six studies were finally included,and the methodological quality was moderately high.Meta-analysis results showed that il-6 level in patients with functional dyspepsia had a strong positive correlation with anxiety,and the difference was statistically significant[summary r=0.72,95%CI(0.65,0.77),P<0.00001].Level of IL-6 in patients with functional dyspepsia had an extremely strong positive correlation with depression,and the difference was statistically significant[summary r=0.83,95%CI(0.66,0.92),P<0.00001],subgroup analysis results showed that the HAMD scale groups:Level of IL-6 in patients with functional dyspepsia had an extremely strong positive correlation with depression,and the difference was statistically significant[summary r=0.91,95%CI(0.18,0.99),P<0.00001],SDS scale groups:Level of IL-6 in patients with functional dyspepsia had strong positive correlation with depression,and the difference was statistically significant[summary r=0.78,95%CI(0.64,0.87),P<0.00001].The sensitivity analysis showed that the results were stable.Conclusion:IL-6 level in patients with functional dyspepsia is strongly correlated with anxiety and depression.However,the credibility and scientificity of the above conclusions ar

关 键 词：功能性消化不良 抑郁 焦虑 白细胞介素-6 META分析 病例-对照研究 

分 类 号：R256.3[医药卫生—中医内科学]