CML、Asprosin与2型糖尿病患者颈动脉粥样硬化的关系  

Relationship between CML,Asprosin and carotid atherosclerosis in type 2 diabetes

作　　者：刘书苑 陈小敏[1] LIU Shuyuan;CHEN Xiaomin(Department of Endocrinology,Zhongshan Hospital,Xiamen University,Xiamen,Fujian,China,361000)

机构地区：[1]厦门大学附属中山医院内分泌科,福建厦门361000

出　　处：《分子诊断与治疗杂志》2020年第11期1457-1460,1465,共5页Journal of Molecular Diagnostics and Therapy

基　　金：厦门市科技计划医疗卫生项目(3502Z20184039)。

摘　　要：目的探讨2型糖尿病(T2DM)患者血清Nε-羧甲基赖氨酸(CML)、及白脂素(Asprosin水平与颈动脉粥样硬化(CAS)的关系。方法将135例T2DM患者根据颈动脉超声检查颈动脉内膜中层厚度(IMT)结果分为颈动脉粥硬化组(CAS组=79)和非颈动脉粥样硬化组(NCAS组=56),另选取60例健康体检者作为对照组(NC组),对比各组临床一般资料、血生化指标等,并采用酶联免疫吸附法(ELISA)检测血清CML、Asprosin,采用Pearson相关性分析和多元线性回归分析CML、Asprosin与其他指标的相关性。logistic回归分析CML、Asprosin是否为颈动脉粥样硬化进展危险因素。结果 T2DM合并CAS组CML、Asprosin显著高于NCAS组和NC组NCAS组显著高于NC组,3组间比较差异具有统计学意义(P<0.05)。相关性分析结果显示,CML、Asprosin相互之间且与糖尿病病程、FPG、HOMI-IR、TC、TG、LDL-C、HbA1C存在正相关性(P<0.05);多元线性回归分析结果显示,糖尿病病程、FPG、HOMI-IR、TC、TG为影响CML及Asprosin水平的独立危险因素。logistic回归分析,提示CML、Asprosi、糖尿病病程、FPG、HOMI-IR均为颈动脉粥样硬化的危险因素。结论 T2DM合并颈动脉粥样硬化患者CML、Asprosin显著升高,提示糖脂毒性和氧化应激,导致内皮损伤,促进颈动脉粥样硬化的发生、进展。Objective To investigate the relationship between serum Nε-carboxymethyllysine(CML)and Asprosin levels and carotid atherosclerosis(CAS)in patients with type 2 diabetes(T2 DM).Methods 135 patients with T2 DM were divided into the carotid atherosclerosis group(CAS group,79)and the non-carotid atherosclerosis group(NCAS group,56)according to carotid ultrasound examination of carotid intima-media thickness(IMT),another 60 healthy people were selected as the control group(NC group).The clinical general data and blood biochemical indicators of each group were compared,and the serum CML and Asprosin were detected by enzyme-linked immunosorbent assay(ELISA).The correlation between CML and Asprosin and other indicators were analyzed by Pearson correlation analysis and multiple linear regression analysis.Logistic regression analysis was used to analyze whether CML and Asprosin were risk factors for carotid atherosclerosis progression.Results(1)In the T2 DM combined with CAS group,CMLand Asprosin were significantly higher than those in the T2 DM without CAS group and the control group.And the non-CAS group was significantly higher than in the control group.The differences among the three groups were statistically significant(P<0.05).(2)Pearson correlation analysis results showed that there was a positive correlation between CML,Asprosin and the duration of diabetes,FPG,HOMI-IR,TC,TG,LDL-C(P<0.05).The multiple linear regression results showed that the course of diabetes,FPG,HOMI-IR,TC,TG are independent risk factors that affect the levels of CML and Asprosin.(3)Logistic regression analysis showed that CML、Asprosin and the course of diabetes,FPG and HOMI-IR were all risk factors for carotid atherosclerosis in patients with type 2 diabetes.Conclusion CML and Asprosin are significantly increased in patients with T2 DM and carotid atherosclerosis,suggesting that glycolipid toxicity and oxidative stress lead to endothelial damage and promote the occurrence and progression of carotid atherosclerosis.

关 键 词：2型糖尿病 颈动脉粥样硬化 Nε-羧甲基赖氨酸 血清白脂素 

分 类 号：R587.2[医药卫生—内分泌] R543.4[医药卫生—内科学]