血清凋亡分子caspase-3、P53与突发性耳聋病情及治疗效果的相关性  

Correlation between serum apoptosis molecules caspase-3,p53 and the disease condition and therapeutic effect of sudden deafness

作　　者：王智超[1] 乐海桂 WANG Zhichao;YUE Haigui(Otorhinolaryngology Department,Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei,China,430022;Otorhinolaryngology Department,Sinopharm Dongfeng Maojian Hospital,Shiyan,Hubei,China,442012)

机构地区：[1]华中科技大学同济医学院附属协和医院耳鼻咽喉科,湖北武汉430022 [2]国药东风茅箭医院耳鼻喉科,湖北十堰442012

出　　处：《分子诊断与治疗杂志》2020年第11期1497-1500,共4页Journal of Molecular Diagnostics and Therapy

基　　金：湖北省自然科学基金青年项目(2017CFB269)。

摘　　要：目的研究血清凋亡分子caspase-3、P53与突发性耳聋病情及治疗效果的相关性。方法选择2018年9月至2019年6月本院耳鼻喉科收治的50例突发性耳聋患者作为观察组,取同期体检的50例健康志愿者作为对照组,检测血清中caspase-3、P53的含量。评估观察组患者的病情及疗效,采用ROC曲线分析caspase-3、P53对疗效的预测价值。结果观察组患者血清中caspase-3、P53的含量高于对照组,差异有统计学意义(P<0.05),且不同听力损伤程度及听力曲线类型患者比较,血清caspase-3、P53含量比较,差异有统计学意义(P<0.05);观察组中caspase-3、P53含量>中位数患者的治疗总有效率低于caspase-3、P53含量≤中位数的患者,差异有统计学意义(P<0.05);血清caspase-3、P53含量对疗效具有预测价值,最佳截点分别为14.76 pg/mL、0.835 ng/mL。结论血清凋亡分子caspase-3、P53增多与突发性耳聋的发生、病情加重及治疗效果可能有关。Objective To study the correlation between serum apoptotic molecules Caspase-3,p53 with the disease condition and the therapeutic effect of sudden deafness.Methods 50 patients with sudden deafness admitted to our hospital from September 2018 to June 2019 were selected as the observation group,and50 healthy volunteers were selected as the control group.The serum levels of Caspase-3 and p53 were detected.The disease condition and curative effect of the observation group were evaluated,and the predictive value of Caspase-3 and p53 on curative effect was analyzed by ROC curve.Results The levels of serum caspase-3 and p53 in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05),and the differences of serum caspase-3 and p53 levels of patients with different degree of hearing impairment and type of hearing curve,the difference was statistically significant(P<0.05);the total effective rate of patients with Caspase-3,p53 content>median in the observation group was lower than that in the patients with caspase-3 and p53 content≤median,the difference was statistically significant(P<0.05).Serum Caspase-3 and p53 levels have predicted value on curative effect,the best cut-off points 14.76 pg/mL,0.835 ng/mL respectively.Conclusion The increase in serum apoptotic molecules caspase-3 and P53 is related to the occurrence,aggravation of the disease and the therapeutic effect of sudden deafness.

关 键 词：突发性耳聋 凋亡 caspase-3、P53 疗效 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]