石菖蒲挥发油中主要成分α-和β-细辛醚的神经药理学作用及机制研究进展  

Research progress on the neuropharmacological effects and mechanisms about the main componentsα-andβ-asarone in volatile oils of Acorus tatarrinowii Schott

作　　者：徐飞飞 李钦青 楚世峰[2] 贺文彬 XU Fei-fei;LI Qin-qing;CHU Shi-feng;HE Wen-bin(Shanxi Key Laboratory of Chinese Medicine Encephalopathy,Shanxi University of Chinese Medicine,Taiyuan 030619,China;Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China)

机构地区：[1]山西中医药大学中医脑病学山西省重点实验室,太原030624 [2]中国医学科学院药物研究所,北京100050

出　　处：《天然产物研究与开发》2020年第11期1969-1979,共11页Natural Product Research and Development

基　　金：国家自然科学基金(81473375);山西省重点研发计划(国际科技合作)重大区域创新合作项目(201803D421006,201903D421018);山西省回国留学人员科研资助项目(2013-134)。

摘　　要：石菖蒲是我国一种药用历史悠久的传统中药。现代研究发现石菖蒲中含有挥发油类、黄酮类、生物碱类、氨基酸类及糖类等多种化学成分,其中挥发油类为主要活性成分,包括α-细辛醚、β-细辛醚等。研究表明α-细辛醚、β-细辛醚具有广泛的药理活性,极具开发价值。近年来,尤其在抗神经系统疾病的研究中,α-和β-细辛醚已经受到国内外学者的极大关注。本文通过对石菖蒲活性物质α-和β-细辛醚的神经药理作用进行总结归纳,重点探讨其在抗脑缺血再灌注损伤中的潜在机制,为深入研究与开发石菖蒲提供依据。Acorus tatarrinowii Schott is a traditional Chinese herbal with a long history of medicinal application.It had been found in modern research that it contains many chemical components such as volatile oils,flavonoids,alkaloids,aminoacids,and saccharides,among which volatile oils are the principal active components.α-Asarone andβ-asarone,the effective ingredients of volatile oils,are considered to have great potential for drug development due to their extensive bioactivities.Furthermore,the effects ofα-asarone andβ-asarone on nervous system disorders have aroused great concern worldwidely.To further investigate and develop the neuropharmacological effects ofα-asarone andβ-asarone as well as A.tatarrinowii,we review and discuss their underlying mechanisms in cerebral ischemia injury and ischemia-reperfusion injury in this article.

关 键 词：Α-细辛醚 Β-细辛醚 神经系统疾病 脑缺血再灌注损伤 

分 类 号：R285[医药卫生—中药学]