山竹果皮中异戊烯基双苯吡酮类成分  

Prenylated xanthones from the pericarps of Garcinia mangostana

作　　者：汤卓雅 潘月华 张君生 尹胜[1] 唐贵华[1] TANG Zhuoya;PAN Yuehua;ZHANG Junsheng;YIN Sheng;TANG Guihua(School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;School of Biological Science and Technology,University of Jinan,Jinan 250022,China)

机构地区：[1]中山大学药学院,广东广州510006 [2]济南大学生物科学与技术学院,山东济南250022

出　　处：《中山大学学报（自然科学版）》2020年第6期21-32,共12页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：国家自然科学基金项目(81973203);广东省基础与应用基础研究基金(2020A1515010841);广东省中医药局项目(20191058);广东省新药设计与评价重点实验室(2017B030314030)。

摘　　要：从山竹(Garcinia mangostana)的果皮中分离得到22个双苯吡酮类化合物,经波谱数据分析分别鉴定为:1,3,7-三羟基𠮿酮(1)、1,3,6,7-四羟基-8-异戊烯基𠮿酮(2)、1,3,5-三羟基-4-异戊烯基𠮿酮(3)、8-deoxygartanin(4)、cudraxanthone G(5)、gartanin(6)、6-脱氧-γ-倒捻子素(7)、γ-倒捻子素(8)、α-倒捻子素(9)、1,3-二羟基-6,7-二甲氧基-2,8-二异戊烯基𠮿酮(10)、β-倒捻子素(11)、garcinone D(12)、garcinone B(13)、mangostenone D(14)、3-O-methylmangostenone D(15)、9-hydroxycalabaxanthone(16)、11-羟基-1-异倒捻子素(17)、brasilixanthone B(18)、garcimangosxanthone D(19)、BR-xanthone A(20)、tovophyllin A(21)和1,3,6-trihydroxy-2,5-bis(3-methylbut-2-enyl)-6',6'-dimethyl-4',5'-dihydropyrano[2,3':7,8]xanthone(22)。其中化合物2~22为异戊烯基双苯吡酮类,且化合物3和15属首次从山竹中分离。在小鼠海马神经元HT22细胞上测试了所有化合物对谷氨酸诱导的细胞死亡的保护活性。Phytochemical investigation on the pericarps of Garcinia mangostana resulted in the isolation of 22 xanthones.On the basis of the spectroscopic data,the structures of these known compounds were identified as 1,3,7-trihydroxyxanthone(1),1,3,6,7-tetrahydroxy-8-prenylxanthone(2),1,3,5-trihydroxy-4-prenylxanthone(3),8-deoxygartanin(4),cudraxanthone G(5),gartanin(6),6-deoxy-γ-mangostin(7),γ-mangostin(8),α-mangostin(9),1,3-dihydroxy-6,7-dimethoxy-2,8-diprenylxanthone(10),β-mangostin(11),garcinone D(12),garcinone B(13),mangostenone D(14),3-Omethylmangostenone D(15),9-hydroxycalabaxanthone(16),11-hydroxy-1-isomangostin(17),brasilixanthone B(18),garcimangosxanthone D(19),BR-xanthone A(20),tovophyllin A(21),and 1,3,6-trihydroxy-2,5-bis(3-methylbut-2-enyl)-6',6'-dimethyl-4',5'-dihydropyrano[2,3':7,8]xanthone(22).Compounds 2-22 were prenylated xanthones,and 3 and 15 were isolated from this plant for the first time.The neuroprotective effects of all compounds against glutamate-induced cell death were tested in murine hippocampal neuronal cell line HT22.

关 键 词：藤黄科(Guttiferae) 山竹(Garcinia mangostana) 异戊烯基双苯吡酮 神经保护活性 

分 类 号：O625.4[理学—有机化学]