直接酰胺化催化合成色酚AS-PH的研究  

Catalytic synthesis of naphthol AS-PH through direct amidation

作　　者：韩焕蓬 姚斌[2] 武玉民[1] 冯维春[2] 舒永 HAN Huan-peng;YAO Bin;WU Yu-min;FENG Wei-chun;SHU Yong(College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China;Shandong Chemical Industry Research Institute,Jinan 250014,China)

机构地区：[1]青岛科技大学化工学院,山东青岛266042 [2]山东省化工研究院,山东济南250014

出　　处：《现代化工》2020年第11期127-130,135,共5页Modern Chemical Industry

基　　金：泰山学者工程专项经费资助(ts20130918);山东省重大科技创新工程项目(2018CXGC1016)。

摘　　要：为有效地解决传统合成色酚AS-PH方法中产生废盐、废酸的问题,采用直接酰胺化方法合成色酚AS-PH。以芳基硼酸为催化剂,考察了催化剂种类、催化剂摩尔分数、溶剂配比、反应时间以及反应温度对合成反应的影响。结果表明,在邻氨基苯乙醚作原料和溶剂、酸胺配比为1∶8、20%苯硼酸作催化剂、反应温度为170℃、反应时间为3.5 h的最佳反应条件下,色酚AS-PH的收率可达80%以上,母液套用次数可达20次。To solve the problems of waste salt and waste acid in traditional synthesis methods,direct amidation method is used to synthesize naphthol AS-PH. Aryl boric acid is used as catalyst to investigate the effects of catalyst type,catalyst dosage,solvent ratio,reaction time and reaction temperature on the synthesis. The results show that the yield of naphthol AS-PH exceeds 80% under the optimal reaction conditions that o-aminophenetidine is used as both raw material and solvent,the ratio of acid to amine is 1∶ 8,20% phenylboronic acid as catalyst,reaction performs at 170℃ for3. 5 h. Mother liquor can be used up to 20 times.

关 键 词：一步法合成 直接酰胺化 催化 羧酸 胺 

分 类 号：O621.3[理学—有机化学]