降钙素原对指导小儿系统性炎症反应综合征抗菌药物治疗的临床分析  

Clinical Analysis of Procalcitonin in Guiding Antimicrobial Treatment of Children with Systemic Inflammatory Response Syndrome

作　　者：冯远超 FENG Yuan-chao(Department of Internal Medicine,Guangning County Maternal and Child Health Hospital,Zhaoqing,Guangdong Province,526300 China)

机构地区：[1]广宁县妇幼保健院内科,广东肇庆526300

出　　处：《中外医疗》2020年第31期87-89,共3页China & Foreign Medical Treatment

摘　　要：目的探讨降钙素原对指导小儿系统性炎症反应综合征抗菌药物治疗的临床效果。方法随机抽取2018年6-12月到该院进行医治的180例系统性炎症反应综合患儿,将其分为参照组和研究组,每组90例。其中参照组实行常规治疗,研究组应用纳入降钙素原予以指导治疗,分析讨论两组的临床分析结果。结果研究组住院时间(7.05±1.19)d、住院费用(3026.15±169.21)元、抗菌药物使用时间(6.85±0.83)d、抗菌药物使用费用(350.23±9.96)元及抗菌药物使用频率(54.44%)明显低于参照组[(9.64±1.93)d、(4082.35±180.05)元、(9.70±1.02)d、(480.23±11.93)元、(93.33%)],差异有统计学意义(P<0.05);研究组的治疗总有效率(97.77%)明显优于参照组,差异有统计学意义(χ^2=10.978,P<0.05);两组患者病死率、MODS及感染性休克发生率相比,差异无统计学意义(P>0.05)。结论系统性炎症反应综合征依据血浆降钙素原进行指导治疗,能增强对抗菌药物的使用率,强化患儿的治疗效果,值得大力推广。Objective To investigate the clinical effect of procalcitonin on guiding antimicrobial treatment of children with systemic inflammatory response syndrome.Methods A random sample of 180 patients with systemic inflammatory response who came to the hospital from June to December 2018 for treatment was divided into a reference group and a study group,with 90 cases in each group.Among them,the reference group was given conventional treatment,and the study group should include procalcitonin to guide treatment,and the clinical analysis results of the two groups were analyzed and discussed.Results The length of stay in the study group was(7.05±1.19)d,the hospitalization expenses were(3026.15±169.21)yuan,and the use time of antibiotics(6.85±0.83)d,the use of antibacterial drugs(350.23±9.96)yuan and the rate of use of antibiotics(54.44%)were significantly lower than the reference group(9.64±1.93)d,(4082.35±180.05)yuan,(9.70±1.02)d,(480.23±11.93)yuan,(93.33%),the difference was statistically significant(P<0.05);The total effective rate of treatment in the study group(97.77%)was significantly better than that in the reference group,the difference was statistically significant(χ^2=10.978,P<0.05);There was no statistically significant difference in mortality,MODS and septic shock between the two groups(P>0.05).Conclusion Systemic inflammatory response syndrome is guided by plasma procalcitonin,which can increase the use rate of antibacterial drugs and strengthen the treatment effect of patients.It is worthy of promotion.

关 键 词：系统性炎症反应综合征 降钙素原 抗菌药物 

分 类 号：R720.597[医药卫生—急诊医学]