基于滚压式血泵的溶血相关影响因素研究  

Research on influencing factors of hemolysis based on rolling blood pump

作　　者：蒋子昂 王陶涛 程加乐 展格格 谷雪莲[1] Jiang Ziang;Wang Taotao;Cheng Jiale;Zhan Gege;Gu Xuelian(College of Medical Devices and Food,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学医疗器械与食品学院,200093

出　　处：《国际生物医学工程杂志》2020年第2期123-127,134,共6页International Journal of Biomedical Engineering

基　　金：上海市大学生创新创业训练计划(SH2017138)。

摘　　要：目的研究体外循环中,滚压式血泵参数以及血液浓度对溶血的影响。方法根据体外溶血实验标准,搭建体外循环实验装置,分析不同循环时间(0~90 min)、血液流速(1~4 L/min)、血液体积分数(60%、70%)对循环系统中血样溶血的影响,并采用一阶线性回归对结果进行分析。结果血泵的循环时间越长,溶血率越大;血液流速越高,溶血率越大。在流速为1和2 L/min时,溶血率曲线有随时间变化的拐点,即当循环时间超过30 min后,溶血率曲线斜率突然增大;但流速在3和4 L/min时,溶血突变现象则不明显。与血液体积分数为70%时相比,血液体积分数为60%的血样更不容易发生溶血。结论血泵循环时间越长、血泵转速越高(血液流速越高),血红细胞越容易发生破坏,即溶血率与循环时间和血液流速成正比。循环时间增长到一定程度时,溶血率曲线出现拐点,此时溶血趋势会明显增强。Objective To study the effects of rolling blood pump parameters and blood concentration on hemolysis during extracorporeal circulation.Methods According to the extracorporeal hemolysis experiment standard,an extracorporeal circulation experimental device was built to analyze the influences of circulation time(0~90 min),blood flow rate(1~4 L/min),and blood volume fraction(60%,70%)on the hemolysis of blood samples in the circulatory system.The results of hemolysis were analyzed using first-order linear regression.Results The longer the blood pump circulation time,the greater the hemolysis rate;the higher the blood flow rate,the greater the hemolysis rate.When the flow rate is 1 and 2 L/min,the hemolysis rate curve has an inflection point that changes with time,i.e.when the circulation time exceeds 30 min,the slope of the hemolysis rate curve suddenly increases.However,when the flow rate is 3 and 4 L/min,the hemolysis mutation phenomenon is not obvious.Compared to the blood sample with blood volume fraction of 70%,a blood sample with a blood volume fraction of 60%is less prone to hemolysis.Conclusions The longer the blood pump circulation time and the higher the blood flow rate,the more easily the red blood cells are destroyed,i.e.the hemolysis rate is directly proportional to the circulation time and blood flow rate.When the circulation time increases to a certain degree,an inflection point appears in the hemolysis rate curve,and the hemolysis trend will be significantly enhanced.

关 键 词：体外循环 滚压式血泵 溶血实验 溶血率 

分 类 号：R654.1[医药卫生—外科学]