水凝胶及其在神经再生中作用的研究进展  

Research progress in hydrogel and their role in nerve regeneration

作　　者：郭景玥 徐兰举 张琳 王淑芳[1] Guo Jingyue;Xu Lanju;Zhang Lin;Wang Shufang(College of Life Science,Nankai University,Key Laboratory of Bioactive Material Materials for Ministry of Education,Tianjin 300071,China)

机构地区：[1]南开大学生命科学学院,生物活性材料教育部重点实验室,天津300071

出　　处：《国际生物医学工程杂志》2020年第2期145-150,共6页International Journal of Biomedical Engineering

摘　　要：水凝胶是一类具有化学或物理交联结构、具有高保湿和高吸水性但不溶于水的三维基质支架材料。水凝胶的生物相容性好、可模仿天然细胞质基质等特点,使其在组织工程、生物医药等领域具有广阔的现实意义和应用前景。神经组织工程是一个有望治疗严重神经疾病的快速发展领域,其中选择合适的基质支架材料并促进神经细胞分化和轴突生长对神经组织工程的总体设计至关重要。水凝胶已广泛用于向组织中递送神经营养因子、神经生长抑制剂的拮抗剂和其他神经生长促进剂,以改善神经系统再生困难的情况,且已被证明是神经组织工程的优秀基质支架材料。对各种已应用于神经相关研究的水凝胶系统进行了分类和讨论,分析了它们的优缺点,讨论了水凝胶在神经组织工程中的前景和面临的挑战。Hydrogel is a kind of three-dimensional matrix scaffold material with chemical or physical cross-linked structure,with high moisture retention and high water absorption,but insoluble in water.Because of its good biocompatibility and the ability to imitate the natural cytoplasmic matrix,hydrogel has broad practical significance and application prospects in the fields of tissue engineering and biomedicine.Nerve tissue engineering is a fast-growing field that is expected to address severe neurological diseases.Choosing the right matrix scaffold material to promote neural cell differentiation and axon growth is critical to the overall design of nerve tissue engineering.Hydrogels have been widely used to deliver neurotrophic factors,antagonists of nerve growth inhibitors and other neural growth-promoting agents to tissues to improve the difficult regeneration of the nervous system,and have proven to be excellent matrix scaffold materials for neural tissue engineering.In this review paper,a variety of hydrogel systems that have been applied to neuro-related research were classified and discussed,and their advantages and disadvantages were analyzed.The prospects and challenges of hydrogels in neural tissue engineering were also discussed.

关 键 词：水凝胶 神经组织工程 神经再生 

分 类 号：R318.08[医药卫生—生物医学工程]