参松养心胶囊联合宁心宝胶囊治疗窦性心动过缓伴室性早搏  

Clinical observation of Shensong Yangxin Capsule with Ning Xinbao Capsule in treatment of sinus bradycardia with ventricular premature beat

作　　者：陈思宇[1] 周晓莉[1] 黄巧娟 刘伟薇 董照瀛 刘昭君 CHEN Siyu;ZHOU Xiaoli;HUANG Qiaojuan;LIU Weiwei;DONG Zhaoying;LIU Zhaojun(Department of Cardiovascular Internal Medicine, The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016, China)

机构地区：[1]重庆医科大学附属第一医院心内科,重庆400016

出　　处：《西部医学》2020年第11期1626-1629,共4页Medical Journal of West China

基　　金：重庆市卫生健康委员会中医药科技项目(ZY201702075)。

摘　　要：目的评价参松养心胶囊联合宁心宝胶囊治疗窦性心动过缓伴频发室性早搏的临床效果。方法选取2018年1月~2019年6月在我院门诊接受治疗的窦缓伴频发室早的患者159例,随机分为对照组1(n=51)、对照组2(n=55)及试验组(n=53)。对照组1给予参松养心胶囊治疗,对照组2给予宁心宝胶囊治疗,试验组给予参松养心胶囊联合宁心宝胶囊治疗。评估3组的治疗效果,包括临床疗效、早搏次数疗效、平均心率疗效。比较3组不良反应的发生情况。结果试验组临床疗效总有效率、早搏疗效总有效率、心动过缓疗效总有效率均优于对照组1、2(均P<0.05);3组不良反应发生率比较差异无统计学意义(P>0.05)。结论参松养心胶囊联合宁心宝胶囊治疗窦缓伴室早较单药治疗能有效改善患者的临床症状,提高平均心率,降低室早次数,同时未增加不良反应,具有一定的临床应用价值。Objective To evaluate the clinical efficacy of Shensong Yangxin Capsule with Ning Xinbao Capsule in the treatment of sinus bradycardia with frequent ventricular premature beat.Methods 159 patients with sinus bradycardia and frequent ventricular premature beats treated in our hospital during Jan.2018~Jun.2019,and they were randomly divided into control group 1(n=51),control group 2(n=55)and test group(n=53).Control group 1 was treated with Shensong Yangxin Capsule.Control group 2 was treated with Ning Xinbao Capsule.Test group was treated with Shensong Yangxin Capsule combined with Ning Xinbao Capsule.The clinical efficacy and safety of the three groups after treatment were observed.Results The total effective rate of symptom improvement in the control group 1,control group 2 and test group was 78%,64%and 52%.There was a significant difference between the three groups(P<0.05).The total effective rate of reducing the number of Ventricular premature beat in the control group 1,control group 2 and test group was 72%,60%and 46%(P<0.05).The total effective rate of improving the average heart rate in the control group 1,control group 2 and test group was 70%,58%and 44%(P<0.5).The incidence of adverse reactions in the control group 1,control group 2 and test group was 3.8%,2%and 0%(P>0.05).Conclusion The combination of Shensong Yangxin Capsule and Ning Xinbao Capsule in the treatment of sinus bradycardia with ventricular premature beats can effectively improve the clinical symptoms of patients,increase the average heart rate and reduce the number of ventricular premature beats,without increasing adverse reactions,which has certain clinical application value.

关 键 词：参松养心胶囊 宁心宝胶囊 窦性心动过缓 室性早搏 

分 类 号：R541.7[医药卫生—心血管疾病]