作用于离子型γ-氨基丁酸受体的异噁唑啉类杀寄生虫剂  

Isoxazoline Parasiticides Acted on Ionotropic GABA Receptors

作　　者：艾大朋 巨修练 刘根炎 Ai Dapeng;Ju Xiulian;Liu Genyan(Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology,Wuhan,430205)

机构地区：[1]武汉工程大学化工与制药学院,绿色化工过程教育部重点实验室,武汉430205

出　　处：《化学通报》2020年第11期986-996,共11页Chemistry

基　　金：国家自然科学基金项目(21807082);湖北省自然科学基金(2017CFB121);湖北省教育厅科学技术研究项目(Q20171503)资助。

摘　　要：离子型γ-氨基丁酸(GABA)受体是一类重要的杀虫剂靶标,异噁唑啉类化合物是作用于该靶标的一类新型杀虫(寄生虫)剂。基于异噁唑啉类衍生物高效的杀虫活性和出色的安全性,自首个该类杀寄生虫剂氟雷拉纳被发现后,阿福拉纳、沙罗拉纳、洛替拉纳和氟噁唑酰胺等化合物相继被报道。本文主要综述了异噁唑啉类化合物在杀虫剂领域的最新研究进展,重点在化学结构、杀虫活性、作用机制、生物代谢和安全性等方面进行了总结和评述,同时探讨了异噁唑啉类杀虫(寄生虫)剂在应用上的局限性,对该类化合物在农业病虫害防治的应用前景和发展趋势作了展望。The insect ionotropicγ-amino-butyric acid(GABA)receptors are an important class of insecticide targets,and isoxazoline analogues are a novel type of insecticides/parasiticides that acted on this target.Since the first isoxazoline parasiticide fluralaner has been identified,novel isoxazolines such as afoxalaner,sarolaner,lotilaner,and fluxametamide have been successively reported based on their effective insecticidal activity and excellent safety.In this paper,we mainly reviewed the latest research progress in the field of isoxazoline insecticides,especially focusing on their chemical structures,insecticidal activities,mechanisms of action,biological metabolisms,and safeties.Moreover,the limitations of the application of isoxazoline insecticides/parasiticides were discussed.Finally,the application prospects and development trends of these isoxazolines in the prevention and management of agricultural pests and diseases were also pointed out.

关 键 词：离子型GABA受体 异噁唑啉 氟雷拉纳 杀寄生虫剂 杀虫剂 

分 类 号：S482.3[农业科学—农药学]