血清H-FABP、CysC及LVEF联合检测对老年冠心病病人预后评估的临床价值  

Value of Serum H-FABP,CysC and LVEF on Prognosis Assessment in Elderly Patients with Coronary Heart Disease

作　　者：向乾才 罗廷福 张娟[1] 张天贵[1] XIANG Qiancai;LUO Tingfu;ZHANG Juan;ZHANG Tiangui(Xichang People′s Hospital,Xichang 615000,Sichuan,China)

机构地区：[1]西昌市人民医院,四川西昌615000

出　　处：《中西医结合心脑血管病杂志》2020年第21期3659-3662,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨血清心型脂肪酸结合蛋白(H-FABP)、胱抑素C(CysC)及左心室射血分数(LVEF)联合检测对老年冠心病(CHD)病人预后评估的临床价值。方法选取2016年1月—2018年1月我院收治的85例CHD病人为CHD组,同期健康体检的老年人50名为对照组。检测两组血清H-FABP、CysC及LVEF。分析CHD病人血清H-FABP、CysC水平与LVEF的相关性,探讨H-FABP、CysC及LVEF联合检测对CHD病人发生不良心血管事件(MACE)的预测价值。结果CHD组血清H-FABP、CysC水平高于对照组(P<0.05),LVEF低于对照组(P<0.05)。不同疾病类型病人血清H-FABP、CysC水平及LVEF比较差异均有统计学意义(P<0.05)。CHD病人血清H-FABP、CysC水平与LVEF均呈负相关(P<0.05),而血清H-FABP与CysC水平呈正相关(P<0.05)。MACE组H-FABP、CysC水平高于非MACE组(P<0.05),而LVEF值低于非MACE组(P<0.05)。H-FABP、CysC及LVEF预测CHD发生MACE的ROC曲线下面积(AUC)分别为0.850,0.842,0.847。3者联合检测的AUC为0.932,预测灵敏度为92.6%,特异度为82.8%。结论老年CHD病人血清H-FABP、CysC水平与心功能和疾病预后存在密切联系,检测血清H-FABP、CysC水平及LVEF值能预测MACE的发生风险。Objective To investigate the value of serum heart-type fatty acid binding protein(H-FABP),cystatin C(CysC)and left ventricular ejection fraction(LVEF)for the prognosis in elderly patients with coronary heart disease(CHD).Methods Eighty-five CHD patients were selected as CHD group and 50 healthy subjects as control group.Serum levels of H-FABP,CysC,and LVEF in two groups were detected.The correlation between serum H-FABP,CysC,and LVEF in CHD patients was analyzed,and the predictive value of H-FABP,CysC,and LVEF in predicting adverse cardiovascular events(MACE)in CHD patients was discussed.Results Serum levels of H-FABP and CysC in CHD group were significantly higher than those in control group(P<0.05),while LVEF was lower than that in control group(P<0.05).The serum levels of H-FABP,CysC,and LVEF in patients with different disease types were statistically different(P<0.05).Serum H-FABP and CysC levels of CHD patients were negatively correlated with LVEF(P<0.05),while serum H-FABP and CysC levels were positively correlated with LVEF(P<0.05).The levels of H-FABP and CysC in MACE group were significantly higher than those in non-MACE group,while the LVEF in MACE group was lower than that in non-MACE group(P<0.05).The area under the curve predicted by H-FABP,CysC,and LVEF for the occurrence of MACE in CHD was 0.850,0.842,and 0.847,respectively.The AUC of combined detection was 0.932,with the sensitivity 92.6%and specificity 82.8%.Conclusion Serum H-FABP and CysC levels in elderly patients with CHD are closely related to cardiac function status and disease prognosis.Detection of serum H-FABP,CysC levels,and LVEF can predict the risk of MACE.

关 键 词：冠心病 心型脂肪酸结合蛋白 胱抑素C 左心室射血分数 预后 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]