神经节苷脂与纳洛酮对重型颅脑损伤患者血清炎性因子与预后的影响  

Effect of ganglioside combined with naloxone in the treatment of patients with severe head injury and the influence on serum inflammatory factors and prognosis

作　　者：刘建熙 秦晓明 王佳惠 LIU Jianxi;QIN Xiaoming;WANG Jiahui(Henan Provincial People's Hospital/Central China Fuwai Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省人民医院华中阜外医院,河南郑州450000

出　　处：《中国实用神经疾病杂志》2020年第21期1891-1895,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20190779)。

摘　　要：目的探讨神经节苷脂联合纳洛酮治疗重型颅脑损伤患者的疗效及对血清炎性因子与预后的影响。方法选取2014-01—2019-12河南省人民医院收治的60例重型颅脑损伤患者,按随机数表法分为2组,对照组采用神经节苷脂治疗,研究组采用神经节苷脂联合纳洛酮治疗,比较2组神经功能变化情况、生存质量、血清炎性因子水平变化及预后情况。结果研究组治疗后NIHSS、中国卒中量表(CSS)评分均低于对照组(P<0.05)。研究组疾病知识、治疗态度、心理状态、疲劳、饮食、精神、睡眠等生存质量评分均高于对照组(P<0.05)。研究组治疗后血清神经肽Y(NYP)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均低于对照组(P<0.05)。与对照组相比,研究组预后更好(P<0.05)。结论神经节苷脂联合纳洛酮治疗重型颅脑损伤的疗效优于单用神经节苷脂,可促进患者神经功能恢复,改善患者预后,提高生存质量,降低致残率。Objective To explore the effectiveness of ganglioside combined with naloxone treatment in patients with severe head injury and its effect on serum inflammatory factors and prognosis.Methods Sixty patients with severe craniocerebral injury admitted in our hospital from January 2014 to December 2019 were selected and divided into two groups according to whether gangliosides were combined with naloxone.The control group used gangliosides alone,the research group applied ganglioside combined with naloxone.The changes of neurological function,quality of life,changes of serum inflammatory factors and prognosis were compared between the two groups.Results After treatment,the NIHSS and CSS scores of the study group were lower than those of the control group(P<0.05);the disease knowledge,treatment attitude,mental state,fatigue,diet,mental and sleep quality of life scores of the study group were higher than the control group(P<0.05).The levels of NYP,TNF-α,and CRP in the study group were lower than those in the control group(P<0.05);compared with the control group,the prognosis of the study group was better(P<0.05).Conclusion Naloxone combined with ganglioside is better than ganglioside alone in the treatment of craniocerebral injury.It can promote the early recovery of nerve function,improve the prognosis of patients,improve the quality of life and reduce the rate of disability.

关 键 词：重型颅脑损伤 神经节苷脂 纳洛酮 神经功能缺损 继发性脑损伤 生存质量 

分 类 号：R651.15[医药卫生—外科学]