鼠神经生长因子联合亚低温治疗新生儿缺氧缺血性脑病临床分析  

Clinical analysis of rat nerve growth factor combined with mild hypothermia in the treatment of neonates with ischemic hypoxic encephalopathy

作　　者：刘俊 赵庆贺[1] LIU Jun;ZHAO Qinghe(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院,河南郑州450052

出　　处：《中国实用神经疾病杂志》2020年第21期1901-1905,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省科技攻关项目(编号:172102310318)。

摘　　要：目的探讨鼠神经生长因子联合亚低温对新生儿缺氧缺血性脑病神经功能的影响。方法选取2014-2019年郑州大学第三附属医院收治的新生儿缺氧缺血性脑病200例,采用随机数字表法分为对照组和观察组各100例。对照组给予亚低温疗法,观察组给予鼠神经生长因子联合亚低温疗法。观察2组新生儿行为神经测定(NBNA)评分、神经反射恢复时间和意识恢复时间、临床症状改善所需时间、智能发育指数(MDI)和运动发育指数(PDI)。结果(1)治疗前2组新生儿NBNA评分比较无显著性差异(P>0.05);治疗后第1周和第2周2组新生儿NBNA评分均显著高于治疗前(P<0.01);观察组治疗后第1周和第2周新生儿NBNA评分均显著高于对照组(P<0.05)。(2)与对照组相比,观察组新生儿神经反射恢复时间显著缩短(P<0.05);观察组新生儿意识恢复时间显著少于对照组(P<0.01)。(3)与对照组相比,观察组新生儿肌张力恢复时间显著缩短(P<0.01),惊厥改善时间显著少于对照组(P<0.05)。(4)观察组新生儿MDI和PDI均显著高于对照组(P<0.05)。结论亚低温疗法和鼠神经生长因子联合亚低温疗法对新生儿缺氧缺血性脑病均有显著效果,但鼠神经生长因子联合亚低温治疗对新生儿缺氧缺血性脑病NBNA评分、神经反射恢复时间和意识恢复时间、临床症状改善所需时间、MDI和PDI改善情况优于亚低温疗法,临床效果更佳。Objective to investigate the effect of rat nerve growth factor(NGF)combined with mild hypothermia on nerve function in newborn with ischemic hypoxic encephalopathy.Methods From 2014 to 2019,200 newborn infants with ischemic hypoxic encephalopathy were selected.The patients were randomly divided into control group and observation group with 100 cases in each group.Patients in the control group were given mild hypothermia therapy,while patients in the observation group were given rat nerve growth factor combined with mild hypothermia therapy.The scores of NBNA,recovery time of nerve reflex and consciousness,time of clinical symptom improvement,intelligence development index(MDI)and motor development index(PDI)were observed.Results Before treatment,there was no significant difference in NBNA score between the two groups(P>0.05).After treatment,the NBNA scores of newborns in both groups at 1-and 2-week were significantly higher than those before treatment(P<0.01).Compared with the control group,the NBNA scores of newborns in the observation group at 1-and 2-week after treatment were significantly higher than those in the control group,and there was a significant difference(P<0.05).Compared with the control group,the recovery time of neonatal nerve reflex in the observation group was significantly shortened,with a significant difference(P<0.05).The recovery time of neonatal consciousness in the observation group was significantly less than that in the control group(P<0.01).Compared with the control group,the recovery time of neonatal muscle tone in the observation group was significantly shortened,with a significant difference(P<0.01).The time required to improve neonatal convulsion in the observation group was significantly less than that in the control group,and there was a significant difference(P<0.05).Compared with the control group,the neonatal intelligence development index and motor development index in the observation group were significantly higher than those in the control group,and there were significant d

关 键 词：缺氧缺血性脑病 鼠神经生长因子 亚低温治疗 神经功能 

分 类 号：R722.1[医药卫生—儿科]