己酮可可碱对创伤失血性休克大鼠心血管功能和血液流变学的影响  

Effects of pentoxifylline on cardiovascular function and hemorheology in rats with traumatic hemorrhagic shock

作　　者：成天军[1] 丁虹 邓志龙[1] CHENG Tianjun;DING Hong;DENG Zhilong(Department of Orthopedics,Chongqing Emergency Medical Center,Chongqing 4000 14,China)

机构地区：[1]重庆市急救医疗中心骨科,400014

出　　处：《重庆医学》2020年第22期3714-3719,共6页Chongqing medicine

基　　金：重庆市民生保障科技创新专项课题(cstc2016shms-ztzx10001)。

摘　　要：目的探讨己酮可可碱(PTX)对液体复苏后创伤失血性休克大鼠心血管功能及血液流变学的影响。方法30只健康雄性Wistar大鼠随机分为3组。采用股骨骨折+颈外静脉放血方法构建创伤失血性休克模型,观察和记录各组大鼠在复苏不同阶段心血管参数变化,同时抽血检测各组血细胞比容(Hct)和全血及血浆黏度改变情况。结果经液体复苏后,PTX组大鼠平均动脉压恢复较明显,复苏后360 min恢复到(83.55±2.40)mm Hg,明显高于LR组的(75.53±7.95)mm Hg(P<0.01);复苏后360 min,PTX组大鼠心率恢复到(447±17)次/分钟,接近SS组的(458±9)次/分钟,明显高于LR组的(376±16)次/分钟(P<0.01);大鼠中心静脉压波动明显,复苏后360 min PTX组为(36.13±2.03)cm H2O,明显低于LR组的(48.44±3.09)cm H2O(P<0.001)。经液体复苏后,两组左心室压力最大上升和下降速度均有不同程度回升,PTX组恢复更明显;液体复苏后PTX组大鼠左心室收缩压(LVSP)逐渐恢复至(122.25±2.70)mm Hg,明显高于LR组的(96.08±7.43)mm Hg(P<0.01)。复苏后4.5、6.5 h,PTX组大鼠Hct、全血及血浆黏度均明显低于LR组(P<0.01)。结论PTX对经液体复苏后创伤失血性休克大鼠有一定疗效,可改善心血管功能及血液流变学指标。Objective To explore the effects of pentoxifylline(PTX)on cardiovascular function and hemorheology in rats with traumatic hemorrhagic shock after fluid resuscitation.Methods A total of 30 healthy male Wistar rats were randomly divided into three groups.The traumatic hemorrhagic shock model was simulated by femur fracture combined with external jugular vein bloodletting method.Cardiovascular parameters at different stages of resuscitation in each group were observed and recorded.Meanwhile,blood samples were drawn to detect the changes of hematocrit(Hct),whole blood and plasma viscosity of each group.Results After fluid resuscitation,the mean arterial pressure of rats in the PTX group recovered significantly,and it increased to(83.55±2.40)mm Hg at 360 min after resuscitation,which was significantly higher than(75.53±7.95)mm Hg of the LR group(P<0.01).At 360 min of resuscitation,the heart rate of the rats in the PTX group increased to(447±17)beats/min,which was close to(458±9)beats/min in the SS group,and was significantly higher than(376±16)beats/min in the LR group(P<0.01).The central venous pressure(CVP)of rats fluctuated significantly,360 min after resuscitation,the CVP in the PTX group was(36.13±2.03)cm H2O,which was significantly lower than(48.44±3.09)cm H2O in the LR group(P<0.001).After fluid resuscitation,maximum speed of increase and decrease in the left ventricular pressure recovered at different degrees in the two groups,and the recovery in the PTX group was more obvious.After fluid resuscitation,the left ventricular systolic pressure(LVSP)of the rats in the PTX group gradually increased to(122.25±2.70)mm Hg,which was significantly higher than(96.08±7.43)mm Hg in the LR group(P<0.01).At 4.5 and 6.5 h after resuscitation,the Hct,whole blood and plasma viscosity of rats in thePTX group were significantly lower than those in the LR group(P<0.01).Conclusion PTX has a certain effect on rats with traumatic hemorrhagic shock after fluid resuscitation,and can improve cardiovascular function and blood rh

关 键 词：己酮可可碱 休克 创伤性 出血 心血管功能 血液流变学 

分 类 号：R459.7[医药卫生—急诊医学]