正常高值血压人群血清炎性标志物研究进展  

Serum Inflammatory Markers in Population with High Normal Blood Pressure

作　　者：赵琳 孟旭 周宪梁[1] ZHAO Lin;MENG Xu;ZHOU Xianliang(Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]北京协和医学院,中国医学科学院国家心血管病中心,阜外医院心血管内科,北京100037

出　　处：《心血管病学进展》2020年第11期1116-1119,共4页Advances in Cardiovascular Diseases

基　　金：国家重点研究发展计划(2016YFC1300100);CAMS医学创新基金(2016-I2M-1-002);协和医学院青年基金(2017-XHQN07)。

摘　　要：正常高值血压范围为收缩压在120~139 mm Hg和/或舒张压在80~89 mm Hg的血压水平。正常高值血压人群后续进展为心血管疾病的风险增加。炎症反应在心血管疾病的发展中起重要作用,但有关正常高值血压和炎症反应之间的研究却十分有限。现总结主要炎症因子如C反应蛋白、白介素-17、白介素-6、肿瘤坏死因子、唾液酸和同型半胱氨酸等在正常高值血压人群中的变化,以期为正常高值血压的机制研究、高危人群的筛选以及心血管疾病的防治提供帮助。High normal blood pressure is defined as a systolic blood pressure of 120~139 mm Hg and/or diastolic blood pressure of 80~89 mm Hg.People with high normal blood pressure have an increased risk of developing cardiovascular disease later in life.Although inflammatory reaction plays an important role in the development of cardiovascular disease,the studies on prehypertension and inflammatory responses are scarce.The purpose of this study is to summarize the changes of major inflammatory factors such as C-reactive protein,interleukin 17,interleukin 6,tumor necrosis factor,sialic acid and homocysteine in prehypertensive population.This information will hopefully help with the mechanism research of high normal blood pressure,screening the high-risk groups and the prevention of cardiovascular events.

关 键 词：正常高值血压 炎症因子 致病机制 

分 类 号：R544.1[医药卫生—心血管疾病]