血小板功能检测指导经皮冠脉介入术后抗血小板治疗的研究进展  

Platelet Function Tests to Guide Antiplatelet Therapy after Percutaneous Coronary Intervention

作　　者：孙伯晨 韩薇[1] SUN Bochen;HAN Wei(Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2020年第11期1132-1136,共5页Advances in Cardiovascular Diseases

摘　　要：抗血小板治疗是冠心病二级预防的基石,国内外指南均推荐对于急性冠脉综合征患者接受阿司匹林联合P2Y12受体拮抗剂可有效地减少经皮冠脉介入术后血栓事件的发生率,但同时增加了出血事件的发生。研究证实血小板反应的多样性与急性冠脉综合征患者长期预后密切相关,目前,国际上对不同血小板功能检测方法的预测价值和诊断界值存在较大争议。因此,现对血小板功能检测方法、血小板反应性预测临床事件的临界值及最新抗血小板治疗研究进展进行综述。Antiplatelet therapy is the basis of secondary prevention about coronary heart disease.Domestic and foreign guidelines recommend that aspirin combined with P 2Y 12 receptor antagonist can effectively reduce thrombosis after percutaneous coronary intervention in acute coronary syndrome patients,but at the same time increased the incidence of bleeding events.Many studies have confirmed that the diversity of platelet response are closely related to the long-term prognosis of acute coronary syndrome patients.Currently,single platelet function test is an universal problem in the world,and the critical value of P 2Y 12 receptor antagonist for high residual platelet reactivity are controversial.Therefore,this platelet function test methods,the predicted value of platelet reactivity for clinical events,and the recent antiplatelet therapy research progress are summarized as follows.

关 键 词：血小板功能检测 血小板反应性 血栓事件 出血事件 抗血小板治疗 

分 类 号：R541.4[医药卫生—心血管疾病]