急性心肌梗死介入术后瑞舒伐他汀强化治疗对炎性因子及心功能的影响  

Influence of rosuvastatin intensive treatment on serum inflammatory factors and cardiac function for patients with acute myocardial infarction after coronary intervention

作　　者：高兰兰[1] 武文君[1] 沙莎 年静[1] GAO Lan-lan(Dept.of cardiology,the second affiliated hospital of Bengbu Medical College,Anhui,Bengbu,233000,China)

机构地区：[1]蚌埠医学院第二附属医院心内科,安徽蚌埠233000

出　　处：《齐齐哈尔医学院学报》2020年第17期2122-2125,共4页Journal of Qiqihar Medical University

摘　　要：目的探讨急性心肌梗死择期PCI术后瑞舒伐他汀强化疗效及对血清炎性因子水平、心功能影响。方法选择2016年1月—2018年8月本院心内科收治的急性心肌梗死并择期行PCI术患者80例作为研究对象,随机分为对照组和研究组两组,每组各40例。对照组给予瑞舒伐他汀10 mg每晚一次常规治疗,研究组给予瑞舒伐他汀20 mg每晚一次,随访半年比较两组的疗效以及对血清炎性因子、心功能的影响。结果治疗前两组患者体内的炎性因子水平无显著差异(P>0.05);治疗后研究组炎性因子水平明显低于对照组(P<0.05)。治疗前两组患者的血清BNP前体、心脏超声指标无显著差异(P>0.05);治疗后研究组血清BNP前体水平明显低于对照组,心功能明显改善(P<0.05)。在临床辅助疗效方面,治疗后研究组总有效率明显高于对照组(P<0.05)。结论急性心肌梗死PCI术后瑞舒伐他汀强化治疗疗效显著,可以明显降低血清炎性因子水平,有效改善心功能。Objective To investigate the influence of rosuvastatin intensive treatment on serum inflammatory factor and cardiac function in patients with acute myocardial infarction after coronary intervention.Methods 80 cases of patients those admitted to our hospital from January 2016 to August 2018 and received PCI were en rolled as study subjects,they were divided to control group and study group,40 cases in each group.The control group adopted conventional treatment of rosuvastatin(10 mg,take in the evening),the study group on the basis of the control group combined with intensive treatment of rosuvastatin(20 mg,take in the evening).The efficacy of the two groups and it's influence on serum inflammatory factor and cardiac function was compared.Results There was no significant difference in inflammatory factors between the two groups before treatment(P>0.05).The inflammatory factors in the study group were significantly lower than those in the control group after treatment(P<0.05).There was no significant difference in BNP precursors and cardiac ultrasound indicators between the two groups before treatment(P>0.05).After the treatment,the level of serum proBNP in the study group was significantly lower than that in the control group,and cardiac function was significantly improved(P<0.05).In terms of clinical auxiliary effect,the auxiliary effect of the study group after coronary intervention was significantly higher than that of the control group(P<0.05).Conclusions Intensive treatment of Rosuvastatin has a good auxiliary effect after percutaneous coronary intervention,which could significantly reduce serum inflammatory factors levels in patients,and effectively improve cardiac function.

关 键 词：急性心肌梗死 PCI术 瑞舒伐他汀 炎性因子 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]