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作 者:赵萍[1] 谢长好[1] 李志军[1] 赵颖[1] ZHAO Ping(Department of Rheumatology Immunology,the first affiliated hospital of Bengbu Medical College,Bengbu,Anhui,233004,China)
机构地区:[1]蚌埠医学院第一附属医院风湿免疫科,安徽蚌埠233004
出 处:《齐齐哈尔医学院学报》2020年第17期2144-2146,共3页Journal of Qiqihar Medical University
基 金:2013年度安徽高校省级科学研究项目(KJ2013-B139)。
摘 要:目的探讨免疫吸附治疗活动期系统性红斑狼疮患者的临床疗效和安全性。方法选择2015年1月—2017年12月在本院进行过免疫吸附治疗的活动期系统性红斑狼疮患者29例作为研究对象,分析比较其治疗前后抗核抗体(ANA)、抗DNA双链抗体(ds-DNA)、免疫球蛋白(IgG、IgA、IgM)、补体(C3、C4)及SLE疾病活动度(SLEDAI)评分的变化;观察患者在进行免疫吸附治疗过程中出现的不良反应及预后。结果免疫吸附治疗后,患者的抗核抗体(ANA)、抗DNA双链抗体(ds-DNA)、免疫球蛋白G(IgG)及SLE疾病活动度(SLEDAI)评分均较治疗前明显下降,差异具有统计学意义(P<0.05);免疫球蛋白A、M(IgA、IgM)差异具无统计学意义(P>0.05);补体(C3、C4)水平较吸附前有所升高,差异具有统计学意义(P<0.05);治疗过程中不良反应如下:胸闷心悸4例,血压轻度下降2例,腹痛2例及面部潮红2例,均予以对症处理后好转。结论免疫吸附治疗活动期系统性红斑狼疮的疗效较为肯定,能有效的降低患者血清中有害抗体及免疫复合物的水平,改善患者临床症状,且治疗过程中发生的不良反应较少,给予相应治疗后可以得到改善,有较高的安全性。Objective To investigate and analyze the clinical efficacy and safety of immunoadsorption therapy in treating active systemic lupus erythematosus(SLE).Methods Twenty-nine cases of patients suffered with active systemic lupus erythematosus those who accepted immunoadsorption therapy in the department from January 2015 to December 2017 were enrolled as study subjects,serum levels of antinuclear antibodies(ANA),anti-double-stranded DNA antibody(dsDNA),immunoglobulin(IgG,IgA,IgM),complement(C3,C4)and SLE activity score(SLEDAI)were detected and compared before and after immunoadsorption therapy.Results The level of serum ANA,dsDNA,IgG and SLEDAI score were obviously decreased after immunoadsorption treatment,there were statistically significant differences(P<0.05).There were no statistically differences in IgA and IgM(P>0.05).The levels of complement(C3,C4)were increased after treatment,there were statistically significant differences(P<0.05).Adverse reactions during immunoadsorption treatment are as follows:chest congestion and palpitations in 4 cases,blood pressure decreased slightly in 2 cases,abdominal pain in 2 cases and facial flushing in 2 cases,and all of these adverse reactions were improved after expectant treatment.Conclusions The efficacy of immunoadsorption therapy on active systemic lupus erythematosus is positive.It could effectively reduce the level of harmful antibodies and immune complexes in serum of patients,and improve clinical symptoms of patients.And there were fewer adverse reactions which were improved after expectant treatment during the treatment,so it has high security.
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