妊娠合并甲状腺功能减退对妊娠结局的影响  

Pregnancy outcomes of 120 pregnant women with hypothyroidism

作　　者：李蕊珊 郑艳[1] 范姜铱柔 吴雪琴[1] LI Rui-shan(Department of Obstetrics and Gynecology,Longgang central hospital,Shenzhen,Guangdong,518116,China)

机构地区：[1]深圳市龙岗中心医院妇产科,广东深圳518116

出　　处：《齐齐哈尔医学院学报》2020年第17期2186-2188,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨妊娠合并甲状腺功能减退对妊娠结局的影响。方法选择2016年4月—2018年5月本院收治的妊娠合并甲状腺功能减退孕妇120例为观察组,同期产检孕妇120名为对照组,观察两组孕妇妊娠期高血压、妊娠期糖尿病、胎膜早破、产后出血发生率,观察两组胎儿畸形、胎儿生长受限、胎儿窘迫、流产、早产发生率。结果两组孕妇不良结局比较,观察组患者妊娠期高血压发生率为10.8%,显著高于对照组的4.2%,差异具统计学意义(P<0.05);观察组患者妊娠期糖尿病发生率为13.3%,显著高于对照组的3.3%,差异具统计学意义(P<0.05);观察组患者胎膜早破发生率为14.2%,显著高于对照组的4.2%,差异具统计学意义(P<0.05);观察组患者产后出血发生率为9.2%,显著高于对照组的0.8%,差异具统计学意义(P<0.05)。两组胎儿不良结局发生率比较,观察组患者胎儿生长受限发生率为13.3%,显著高于对照组的3.3%,差异具统计学意义(P<0.05);观察组患者胎儿畸形发生率为17.5%,显著高于对照组的0.8%,差异具统计学意义(P<0.05);观察组患者胎儿窘迫发生率为7.5%,显著高于对照组的1.7%,差异具统计学意义(P<0.05);观察组患者流产发生率为9.2%,显著高于对照组的0.8%,差异具统计学意义(P<0.05);观察组患者早产发生率为149.2%,显著高于对照组的0.8%,差异具统计学意义(P<0.05)。结论妊娠合并甲状腺功能减退可以导致胎儿生长受限、胎儿窘迫、胎儿畸形、流产、早产、孕妇产后出血、妊娠期糖尿病、妊娠期高血压发生率增高,严重影响母婴的安全,加强对孕妇甲状腺功能的筛查,积极治疗甲状腺功能减退,可改善妊娠结局。Objective To discuss the the influence of pregnancy with hypothyroidism on pregnancy outcome.Methods 120 pregnant women with hypothyroidism during pregnancy those admitted to our hospital from April 2016 to May 2018 were enrolled as observation group,another 120 pregnant women during the same period were selected as the control group.Incidence of pregnancy hypertension,gestational diabetes mellitus,premature rupture of membranes,postpartum hemorrhage,fetal malformation,fetal growth restriction,fetal distress,abortion,premature delivery rate were observed. Results The incidence of gestational hypertension in the observation group was 10.8%,which was significantly higher than 4.2% in the control group, P <0.05.The incidence of gestational diabetes in the observation group was 13.3%,significantly higher than 3.3% in the control group, P <0.05.The incidence of premature rupture of membranes in the observation group was 14.2%,significantly higher than 4.2% in the control group( P <0.05).The incidence of postpartum hemorrhage in the observation group was 9.2%,significantly higher than 0.8% in the control group( P <0.05).Fetal growth restriction rate in observation group was 13.3%,significantly higher than 3.3% in control group( P <0.05).The incidence of fetal malformation in the observation group was 17.5%,significantly higher than 0.8% in the control group( P <0.05),and the incidence of fetal distress in the observation group was 7.5%,significantly higher than 1.7% in the control group( P <0.05).The incidence of abortion in the observation group was 9.2%,significantly higher than 0.8% in the control group( P <0.05),and the incidence of premature delivery in the observation group was 149.2%,significantly higher than 0.8% in the control group( P <0.05). Conclusions Pregnancy combined with hypothyroidism could lead to fetal growth restriction,fetal distress,fetal malformation,abortion,premature delivery,postpartum hemorrhage,gestational diabetes mellitus and pregnancy-induced hypertension,which seriously affect the safet

关 键 词：妊娠 甲状腺功能减退 甲状腺激素 胎儿 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]