地尔硫[艹卓]对肾移植患者环孢素A血药浓度的影响  

Effect of Diltiazem on blood concentration of Cyclosporine A in renal transplant patients

作　　者：苏丹 陈露 张蕾[1] 沈爱宗 唐丽琴 SU Dan;CHEN Lu;ZHAGN Lei;SHEN Aizong;TANG Liqin(Department of Pharmacy,the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Anhui Province,Hefei230001,China;School of Pharmacy,Anhui University of Chinese Medicine,Anhui Province,Hefei230012,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)药剂科,安徽合肥230001 [2]安徽中医药大学药学院,安徽合肥230012

出　　处：《中国医药导报》2020年第31期99-102,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81603339);安徽省高等学校省级质量工程项目(2018jyxm0719)。

摘　　要：目的探讨临床接受肾移植的患者术后联合使用环孢素A(CsA)与地尔硫[艹卓](DTZ)的临床效果,评估DTZ对肾移植患者CsA血药浓度的影响。方法收集2013年1月—2017年12月在中国科学技术大学附属第一医院(安徽省立医院)接受肾移植手术的患者108例,采用随机数字表法将患者分为对照组(54例)和研究组(54例),对照组的患者术后只单纯使用CsA;研究组则在术后同时应用CsA和DTZ。收集两组术后1~6个月的CsA用量及其血药浓度的数据,分析CsA的肝肾毒性。结果两组患者肾移植术后CsA血药浓度组间及交互作用比较,差异无统计学意义(P>0.05);时间比较,差异有统计学意义(P<0.05)。其中,两组患者术后2~6个月CsA血药浓度低于术后1个月,术后3~6个月CsA血药浓度低于术后2个月,差异有统计学意义(P<0.05)。两组患者CsA用药剂量组间及时间比较,差异有统计学意义(P<0.05);而交互作用比较,差异无统计学意义(P>0.05)。其中术后2、4、6个月CsA用药剂量低于术后1个月,术后3个月低于术后2个月,术后4、6个月低于术后3个月,差异有统计学意义(P<0.05)。治疗后两组患者血肌酐、尿素氮及尿酸水平低于治疗前,差异有统计学意义(P<0.05)。结论DTZ能明显提高CsA的血药浓度,使CsA的用药剂量减少,从而减少CsA的毒副作用,并能减轻患者的经济负担。Objective To explore the clinical effect of combined use of Cyclosporine A(CsA)and Diltiazem(DTZ)in patients undergoing clinical kidney transplantation,and to evaluate the effect of DTZ on the blood concentration of CsA in kidney transplant patients.Methods A total of 108 patients who underwent kidney transplantation at the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)from January 2013 to December 2017 were collected,and they were divided into the control group(54 cases)and the study group(54 cases)by random number table method.The patients in the control group only used CsA after the operation,while the study group received both CsA and DTZ after the operation.The data of CsA dosage and blood drug concentration of two groups one to six months after operation,and the liver and kidney toxicity of CsA were analyzed.Results There were no significant differences in CsA blood concentration and interaction between the two groups after renal transplantation(P>0.05);the difference was statistically significant in time comparison(P<0.05).Among them,the CsA blood concentration two to six months after oparation of the two groups were lower than one month after operation,and the CsA blood concentration three to six months after operation were lower than two months after operation,and the differences were statistically significant(P<0.05).The differences between the two groups in the dose and time of CsA administration were statistically significant(P<0.05);while the interaction comparison,and the difference was not statistically significant(P>0.05).Among them,two,four and six months after operation were lower than one month after operation,the dose of CsA used in three months after operation was lower than two months after operation,while four and six months after operation were lower than three months after operation,and the differences were statistical significance(P<0.05).After treatment,the levels of serum creatinine,urea nitrogen and uric acid between the two group

关 键 词：环孢素A 地尔硫[艹卓] 肾移植 血药浓度 

分 类 号：R699.2[医药卫生—泌尿科学]