参苏温肺汤加减对慢性鼻窦炎患者的肺功能及炎症因子的影响  

Effect of Modified Shensu Wenfei Decoction on pulmonary function and inflammatory factors in patients with chronic sinusitis

作　　者：刘莹 徐建友[1] LIU Ying;XU Jianyou(Department of Otorhinolaryngology,Lishui Hospital of Traditional Chinese Medicine,Zhejiang Province,Lishui 323000,China)

机构地区：[1]浙江省丽水市中医院耳鼻咽喉科,浙江丽水323000

出　　处：《中国医药导报》2020年第32期144-147,共4页China Medical Herald

摘　　要：目的探讨参苏温肺汤加减对慢性鼻窦炎患者肺功能及炎症因子的影响。方法选取浙江省丽水市中医院2018年1月—2020年1月收治的慢性鼻窦炎患者88例,按照随机数字表法分为两组,各44例。对照组给予丙酸氟替卡松联合泼尼松治疗,观察组在对照组的基础上给予参苏温肺汤加减治疗。治疗4周后对两组患者的临床效果、不良反应发生率、治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC],炎症因子[白细胞介素-17(IL-17)、白细胞介素-1β(IL-1β)、γ干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)]水平进行对比研究。结果观察组总有效率明显高于对照组(P<0.05);治疗后,观察组FEV1、FVC、FEV1/FVC水平均明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-17、IL-1β、IFN-γ、TNF-α水平均明显低于对照组,差异有统计学意义(P<0.05);治疗后,两组的不良反应发生率差异无统计学意义(P>0.05)。结论参苏温肺汤加减治疗慢性鼻窦炎可显著改善患者炎症水平,提高肺功能水平,安全性高,值得临床推广应用。Objective To investigate the effect of Modified Shensu Wenfei Decoction on pulmonary function and inflammatory factors in patients with chronic sinusitis.Methods Eighty-eight patients with chronic sinusitis admitted to Lishui Hospital of Traditional Chinese Medicine from January 2018 to January 2020 were selected.All patients were randomly divided into two groups,with 44 cases in each group.The control group was given Fluticasone Propionate combined with Prednisone,and the observation group was treated with Modified Shensu Wenfei Decoction on the basis of control group.After 4 weeks of treatment,the clinical efficacy,incidence of adverse reactions,lung indexes(forced vital capacity[FVC],forced expiratory volume in one second[FEV1],FEV1/FVC),inflammatory cytokines(interleukin-17[IL-17],interleukin-1β[IL-1β],interferon-gamma[IFN-γ],tumor necrosis factor-α[TNF-α])levels were compared between the two groups before and after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);after treatment,the levels of FEV1,FVC and FEV1/FVC in the observation group were significantly higher than those in control group,the differences were statistically significant(P<0.05);after treatment,the levels of IL-17,IL-1β,IFN-γand TNF-αin the observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05);after treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Shensu Wenfei Decoction in the treatment of chronic sinusitis can significantly improve the inflammatory levels and pulmonary function,with high safety,which is worthy of clinical promotion and application.

关 键 词：参苏温肺汤加减 慢性鼻窦炎 肺功能 炎症因子 临床疗效 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]