巨噬细胞胞外陷阱的研究进展  

The research progress of macrophage extracellular traps

作　　者：岳朋朋 郭德良[1] 刘朋朋[1] 陈白杨 刘权焰[1] Yue Pengpeng;Guo Deliang;Liu Pengpeng;Chen Baiyang;Liu Quanyan(Department of Hepatobiliary and Pancreas,Research Center of Digestive Diseases,Zhongnan Hospital,Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院肝胆胰外科,消化性疾病研究中心,武汉大学第二临床学院,430071

出　　处：《中华实验外科杂志》2020年第10期1964-1968,共5页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81872029)。

摘　　要：巨噬细胞是体内固有免疫系统的主要成员之一,以固定细胞或游离细胞的形式对细胞残片及病原体进行吞噬以及消化,并激活淋巴细胞及其他免疫细胞,对病原体作出反应。另外,巨噬细胞也能像中性粒细胞一样,通过一种由颗粒蛋白和DNA构成的称作巨噬细胞胞外陷阱(METs)的结构来捕获病原体。本文就METs的结构、产生及其在炎症和相关疾病中的研究进展进行综述。Macrophages are one of the main members of the innate immune system,they devour and digest cellular debris and pathogens in the form of fixed cells or free cells,and activate lymphocytes or other immune cells to make them respond to pathogens.In addition,like neutrophils,macrophages can also kill microbes by capturing them in extracellular structures consisting of granule proteins and DNA called macrophage extracellular traps(METs).This review summarizes the recent advancements regarding the structure,production and biological relevance of METs.

关 键 词：巨噬细胞 巨噬细胞胞外陷阱 炎症 免疫 

分 类 号：R392.12[医药卫生—免疫学]