基于关联规则挖掘何成瑶教授运用中药人工周期治疗排卵障碍性不孕症规律分析  

Analysis on the rule of traditional Chinese medicine artificial menstrual cycle in the treatment of ovulatory dysfunctional infertility by Professor He Chengyao based on the association rule mining

作　　者：冷安明[1] 杨静[2] 张向华 周佐涛[1] LENG Anming;YANG Jing;ZHANG Xianghua;ZHOU Zuotao(Department of Traditional Chinese Medicine,Guizhou Provincial People’s Hospital,Guizhou Province,Guiyang550002,China;Department of Nursing,Guizhou Provincial People’s Hospital,Guizhou Province,Guiyang550002,China;Department of Gynecology,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guizhou Province,Guiyang550004,China)

机构地区：[1]贵州省人民医院中医科,贵州贵阳550002 [2]贵州省人民医院护理部,贵州贵阳550002 [3]贵州中医药大学第二附属医院妇科,贵州贵阳550004

出　　处：《中国医药导报》2020年第33期153-156,共4页China Medical Herald

基　　金：国家中医药管理局全国老中医药专家学术经验继承工作项目(国中医药人教发〔2017〕29号);贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY-2019-034)。

摘　　要：目的基于中医传承辅助平台挖掘全国名老中医何成瑶治疗排卵障碍性不孕症的用药规律,为排卵障碍性不孕症治疗提供借鉴。方法按照纳入、排除标准收集何成瑶教授诊治的排卵障碍性不孕症处方475首,建立排卵障碍性不孕症数据库,分别检索“黄体期”“卵泡期”“排卵期”“月经期”,利用软件集成统计方法分析何教授治疗本病的用药规律。结果475首处方分析显示排卵障碍性不孕症各期共用药物有蛇床子、熟地黄、当归、五味子、大血藤、菟丝子、川芎、覆盆子、白芍、枸杞子等。从人工周期用药分析,黄体期多用仙茅、淫羊藿、鹿角霜等药物,卵泡期多用麦冬、川断、党参等药物,排卵期多用柴胡、路路通、泽兰等药物,月经期多用核桃仁、蒲黄、五灵脂等药物。结论何成瑶教授治疗排卵障碍性不孕症以补肾养血调经贯穿于全部月经周期,并根据月经周期分别以温阳、养阴、活血、理气等为主。Objective To explore the medication rules of Chinese distinguished veteran doctor of traditional Chinese medicine He Chengyao in the treatment of ovulatory dysfunctional infertility based on the traditional Chinese medicine inheritance support system.Methods According to the inclusion and exclusion criteria,475 prescriptions of ovulatory dysfunctional infertility diagnosed and treated by Professor He Chengyao were collected,and the database of ovulatory dysplastic infertility was established.By searching“luteal phase”“follicular phase”“ovulation phase”and“menstrual phase”respectively and using software integrated statistical methods,the medication rules of Professor He in the treatment of this disease were analyzed.Results The analysis of 475 prescriptions showed that the common drugs used in all stages of the disease included common cnidium fruit,prepared rehmannia root,Chinese angelica,Chinese magnoliavine fruit,sargentgloryvine stem,dodder seed,Sichuan lovage rhizome,palmleaf raspberry fruit,debark peony root,barbary wolfberry fruit,etc.According to the analysis of medication in the artificial menstrual cycle,the drugs such as common curculigo rhizome,epimedium herb and degelatined deer-horn were often used in the luteal phase;the drugs such as dwarf lilyturf tuber,himalayan teasel root and tangshen were often used in the follicular phase;the drugs such as Chinese thorowax root,beautiful sweetgum fruit and hirsute shiny bugleweed herb were often used in the ovulation phase;the drugs such as English walnut seed,cattail pollen and flying squirrel’s droppings were often used in the menstrual phase.Conclusion Professor He Chengyao’s treatment for ovulatory dysfunctional infertility is based on tonifying kidney,nourishing blood and regulating menstruation throughout the whole menstrual cycle.And according to the menstrual cycle,it mainly focuses on warming yang,nourishing yin,promoting blood circulation and regulating qi-flowing.

关 键 词：中医传承辅助平台 关联规则 何成瑶 排卵障碍性不孕症 用药规律 

分 类 号：R271.14[医药卫生—中医妇科学]