低剂量前列地尔对肝移植患者术中PAP和血流动力学的影响  

Effect of Low-dose Alprostadil on Pulmonary Arterial Pressure and Hemodynamics in Patients undergoing Liver Transplantation

作　　者：束云菲 姜一新[1] 李兵[1] SHU Yun-fei;JIANG Yi-xin;LI Bing(Dept.of Anesthesiology,The First People’s Hospital of Kunming,Kunming Yunnan 650011,China)

机构地区：[1]昆明市第一人民医院麻醉科,云南昆明650011

出　　处：《昆明医科大学学报》2020年第11期138-142,共5页Journal of Kunming Medical University

基　　金：昆明市卫生委员会卫生科研基金资助项目(2019-04-11-007)。

摘　　要：目的探讨在原位肝移植术中使用低剂量前列地尔对患者肺动脉压(PAP)血流动力学的影响。方法选择2018年3月至2019年9月在昆明市第一人民医院接受原位肝移植手术的患者22例,随机分为两组,实验组12例,经颈内静脉持续泵入前列地尔[1.5 ng/(kg·min)];对照组10例,经颈内静脉持续泵入等量的生理盐水;比较手术的不同时刻两组患者的平均肺动脉压(MPAP)和血流动力学差异。结果两组患者的基本资料(年龄、性别、身高、体重、ASA分级)和肝移植术中的基本情况(输液量、浓缩红细胞输注量、血浆输注量、失血量、尿量、手术时间、无肝期时间),差异无统计学意义(P>0.05),且在手术的不同时刻,两组患者的MPAP和血流动力学的变,差异无统计学意义(P>0.05)。结论在原位肝移植手术中持续泵入[1.5 ng/(kg·min)]前列地尔对患者的PAP和血流动力学均无明显的影响。Objective To explore the influence of low-dose alprostadil on patients’pulmonary artery pressure(PAP)and hemodynamics in orthotopic liver transplantation.Methods From March 2018 to September2019,22 patients undergoing orthotopic liver transplantation in The First People’s Hospital of Kunming were selected and then they were randomly assigned into two groups.Experimental group(12 cases)was continuously pumped with alprostadil(1.5 ng/kg·min)through internal jugular vein;control group(10 cases)was continuously pumped with the same amount of saline through internal jugular vein.Finally the mean pulmonary artery pressure(MPAP)and hemodynamics of the two groups at different times of the surgery were compared.Results There was no significant difference between the two groups in basic information(age,gender,height,weight,ASA classification)(P>0.05)and basic information in liver transplantation(infusion,concentrated red blood cell concentrate infusion,plasma infusion,blood loss,urine,operation time and anhepatic period time)(P>0.05),also there was no statistically significant difference in MPAP and hemodynamics between the two groups at different times of the surgery(P>0.05).Conclusion Continuous pumping of 1.5 ng/kg·min alprostadil during orthotopic liver transplantation has little effect on PAP and hemodynamics.

关 键 词：前列地尔 肝移植 肺动脉压 漂浮导管 

分 类 号：R453.9[医药卫生—治疗学]