巨噬细胞对凋亡细胞的清除及炎症调控作用  

Clearance of apoptotic cells by macrophages and resolution of inflammation

作　　者：谭海鹏(综述) 黄浙勇(审校) TAN Hai-peng;HUANG Zhe-yong(Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Shanghai Institute of Cardiovascular Diseases,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院心内科,上海200032 [2]上海市心血管病研究所,上海200032

出　　处：《复旦学报（医学版）》2020年第6期911-916,共6页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金面上项目(81870269)。

摘　　要：胞葬作用(efferocytosis)是机体内凋亡细胞被吞噬细胞清除的生理过程,而巨噬细胞是一种重要的吞噬细胞。炎症是机体防御感染及修复损伤的保护性反应,但过度强烈的炎症和持续的慢性炎症则与许多疾病的发生和发展密切相关。巨噬细胞不仅可以通过对凋亡细胞的吞噬来避免炎症的发生,还可以通过在胞葬过程中与凋亡细胞及其代谢产物之间的相互作用获得主动性的抗炎效应。这一抗炎效应对炎症的及时消退及组织损伤后修复和再生过程的启动都至关重要。本文就近年来的研究进展对胞葬作用抗炎效应的产生机制进行综述。Efferocytosis is a physiological process in which apoptotic cells are cleared by phagocytes,and macrophages are one of the most important members of these phagocytes.Inflammation is a protective response of the body against infection and tissue damage,but excessive inflammation and persistent chronic inflammation are closely related to the occurrence and development of many diseases.Macrophages can not only avoid the occurrence of inflammation through the phagocytosis of apoptotic cells,but also obtain an active anti-inflammatory effect by interacting with apoptotic cells and their metabolites during this process.This active anti-inflammatory effect is essential for the timely resolution of inflammation and critical for the initiation of repair and regeneration after tissue damage.This review summarizes the recent research progress related to the mechanism of this active anti-inflammatory effect.

关 键 词：凋亡细胞 巨噬细胞 胞葬作用 炎症调控 机制 

分 类 号：R392.111[医药卫生—免疫学]