隔姜灸防治晚期恶性骨肿瘤患者化疗后呕吐:随机对照研究  

Ginger-partitioned moxibustion in prevention of vomiting induced by chemotherapy in advanced malignant bone tumors: a randomized controlled trial

作　　者：张磊[1] 王娅玲[1] 娄吉昌 夏国杰[1] 徐波 冯守含 关新军[1] ZHANG Lei;WANG Ya-ling;LOU Ji-chang;XIA Guo-jie;XU Bo;FENG Shou-han;GUAN Xin-jun(Huzhou Hospital of TCM,Affiliated to Zhejiang Chinese Medical University,Huzhou 313000,China;Tongzi Hospital of TCM)

机构地区：[1]浙江中医药大学附属湖州市中医院,湖州313000 [2]桐梓县中医院

出　　处：《中国针灸》2020年第11期1164-1168,共5页Chinese Acupuncture & Moxibustion

基　　金：国家中医药管理局“十二五”重点建设专科项目:ZJ1101TN010;浙江省中医药科技研究项目:2013ZST003;傅瑞阳全国名老中医药专家学术经验继承工作建设项目:国医药人教发(2017)29号;浙江省傅瑞阳名老中医专家传承工作室建设项目:浙中医药(2017)28号。

摘　　要：目的:观察隔姜灸对晚期恶性骨肿瘤化疗后消化道反应、生活质量、白细胞计数的影响。方法:将64例患者随机分成观察组和对照组,各32例。两组均采用阿霉素联合顺铂(AP)的化疗方案,对照组于化疗前1h予盐酸托烷司琼(欧必亭)5 mg静脉滴注;观察组在对照组的基础上于化疗后2 h取内关、足三里、神阙、中脘行隔姜灸治疗,每天1次,每次30 min,化疗、隔姜灸和静脉滴注的疗程均为5 d。比较两组患者化疗前1 d、化疗后2 d、化疗后7 d的消化道反应程度评级、生活质量评分和白细胞计数。结果:观察组化疗后2 d、7 d的消化道反应为0级的例数明显多于对照组,而Ⅲ、Ⅳ例数明显少于对照组(P<0.05)。化疗后2d两组生活质量评分均较化疗前降低(P<0.05),组间比较差异无统计学意义(P>0.05);化疗后7 d对照组生活质量评分低于化疗前(P<0.05),观察组生活质量评分与化疗前比较差异无统计学意义(P>0.05),且观察组高于对照组(P<0.05)。化疗后2 d两组白细胞计数均较化疗前降低(P<0.05),组间比较差异无统计学意义(P>0.05);化疗后7 d对照组白细胞计数低于化疗前(P<0.05),而观察组与化疗前比较差异无统计学意义(P>0.05),且观察组高于对照组(P<0.05)。结论:隔姜灸可防治晚期恶性骨肿瘤化疗后呕吐,提高患者生活质量和白细胞计数水平。Objective To observe the effect of ginger-partitioned moxibustion on digestive tract reaction, quality of life and white blood cell count after chemotherapy in advanced malignant bone tumors patients. Methods A total of 64 patients were randomly divided into an observation group and a control group, 32 cases in each group. Both groups were treated with adriamycin combined with cisplatin(AP) chemotherapy. The patients in the control group were treated by tropisetron hydrochloride intravenous on preventing the vomiting 1 h before receiving chemotherapy. On the basis of the control group, the patients in the observation group were treated with ginger-partitioned moxibustion at Neiguan(PC 6), Zusanli(ST 36), Shenque(CV 8), and Zhongwan(CV 12) 2 h after chemotherapy, once a day, 30 min each time. The course of chemotherapy,ginger-partitioned moxibustion and tropisetron hydrochloride intravenous was 5 days. The digestive tract reaction rating,quality of life score and white blood cell count were compared 1 d before chemotherapy, 2 d after chemotherapy and 7 d after chemotherapy between the two groups. Results The number of 0 grade in digestive tract reaction 2 d and 7 d after chemotherapy in the observation group was significantly higher than that in the control group(P<0.05), and the number ofⅢ、Ⅳ grade was lower than that in the control group(P<0.05). The quality of life scores of both groups 2 d after chemotherapy were lower than those before chemotherapy(P<0.05), and there was no significant difference between the two groups(P>0.05). The quality of life score of the control group 7 d after chemotherapy was lower than that before chemotherapy(P<0.05), the quality of life score of the observation group was not statistically different from that before chemotherapy(P>0.05), and the quality of life score in the observation group was higher than that in the control group(P<0.05).The white blood cell count 2 d after chemotherapy in both groups was lower than before treatment(P<0.05), and there was no significant diff

关 键 词：晚期恶性骨肿瘤 隔姜灸 化疗 呕吐 随机对照试验 

分 类 号：R246.1[医药卫生—针灸推拿学]