糖尿病肾病发生的氧化应激机制及抗氧化治疗的研究进展  

Research progress in oxidative stress mechanisms and antioxidants therapy for diabetic nephropathy

作　　者：张尚维 李明星 赵蕊[1] 应苗法[1] ZHANG Shang-wei;LI Ming-xing;ZHAO Rui;YING Miao-fa(Department of Pharmacy,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院药学部,浙江杭州310016

出　　处：《中国药理学与毒理学杂志》2020年第8期634-640,共7页Chinese Journal of Pharmacology and Toxicology

基　　金：浙江省自然科学基金(LYY19H310010);浙江省自然科学基金(LYY20H310002)。

摘　　要：糖尿病肾病(DN)是临床上常见的糖尿病微血管并发症,其病理特征以肾小球滤过率增加、基底膜和系膜增厚、以及晚期的肾小球硬化和肾小管纤维化为主,是终末期肾疾病的主要原因之一。以往的研究证实,持续的高血糖会导致活性氧簇的过度产生和炎症介质的激活,引起氧化应激损伤,进而导致糖尿病患者的血管和肾受损。目前,由于氧化应激发生的相关通路复杂且靶点较多,以至于DN发病的氧化应激机制仍未阐明。因此,本文主要对DN发生的氧化应激机制与肾炎、肾小球上皮细胞损伤、肾小球硬化和肾小管间充质纤维化的关系及维生素C、维生素E和α-硫辛酸等抗氧化剂治疗DN的进展进行综述,为治疗DN新抗氧化剂的开发提供思路。Diabetic nephropathy(DN)is a clinically common microvascular complication of diabetes and one of the main causes of end-stage renal disease.The main pathological characteristics of DN include an increased glomerular filtration rate,thickness of basement membrane and mesan gium,advanced glomerulosclerosis and renal tubular fibrosis.Previous studies confirmed that persistent hyperglycemia could lead to the excessive production of reactive oxygen species and the activation of inflammatory mediators,causing oxidative stress damage,which in turn could lead to damage to blood vessels and kidneys.Due to the complex pathways and many targets involved in the occurrence of oxidative stress,the mechanism by which oxidative stress is involved in the pathogenesis of DN has not been clearly elucidated.Therefore,this article mainly reviews the relationship between the oxidative stress mechanisms of DN on one hand and nephritis,glomerular epithelial cell damage,glomerular sclerosis and tubular intersti⁃tial fibrosis on the other hand.The progress in the treatment of DN with such antioxidants as vitamins C,vitamins E,andα-lipoic acid is also mentioned.

关 键 词：糖尿病肾病 氧化应激 抗氧化剂 机制 

分 类 号：R963[医药卫生—微生物与生化药学] R365[医药卫生—药理学]