N-取代苯甲酰基-N′-(2-呋喃甲酰胺基)硫脲的合成与除草活研究  

Synthesis and herbicidal activity of N-(substituted benzoyl)-N′-(2-furoylamido)thioureas

作　　者：郑广进[1] 曾振芳[1] ZHENG Guang-jin;ZENG Zhen-fang(Guangxi Colleges and Universities Key Laboratory Breeding Base of Chemistry of Guangxi Southwest Plant Resources, Guangxi Normal University for Nationalities,Chongzuo 532200,China)

机构地区：[1]广西民族师范学院广西高校桂西南特色植物资源化学重点实验室培育基地,广西崇左532200

出　　处：《化学研究与应用》2020年第11期2003-2008,共6页Chemical Research and Application

基　　金：广西民族师范学院校级科研项目(2016YB030)资助。

摘　　要：以取代苯甲酸为原料,经酰氯化、酰化反应得到中间体取代苯甲酰基异硫氰酸酯,再与糠酰肼经加成反应合成了7个N-取代苯甲酰基-N′-(2-呋喃甲酰胺基)硫脲类化合物6a^6g,其中5个未见文献报道。通过1H NMR、13C NMR、MS和元素分析确证其结构。采用油菜平皿法测定目标化合物的除草活性,测试结果表明大部分目标化合物具有较强的除草活性。其中,化合物6a在100 mg·L^-1下对反枝苋、鬼针草、稗草和龙爪茅的根抑制率均达90%以上。Seven N-(substituted benzoyl)-N′-(2-furoylamido)thioureas(6a^6g)were synthesized by addition reaction of furan-2-carbohydrazide and substituted benzoyl isothiocyanates which prepared by acyl chlorination and acylation of substituted benzoic acids.Five of them were new compounds.The structures of these compounds were confirmed by 1H NMR,13C NMR,MS and elemental analysis.Herbicidal activities were evaluated through Brassica napus plate method.The herbicidal activity test showed that most of the target compounds exhibited strong herbicide activities.Among of them,the growth inhibition rates of the roots of Amaranthus retroflexus,Bidens pilosa L,Echinochloa crusgalli Beauv and Dactyloctenium were up to 90%for compound 6a at the dosage of 100 mg·L^-1.

关 键 词：取代苯甲酸 糠酰肼 酰基硫脲 合成 除草活性 

分 类 号：O626.2[理学—有机化学]