核苷化合物的快捷硫化方法  

A rapid thioreaction of nucleoside compounds

作　　者：武文慧 王玉婷 张晓辉[1] 李德鹏[1] WU Wen-hui;WANG Yu-ting;ZHANG Xiao-hui;LI De-peng(College of Environmental and Chemical Engineering,Dalian University,Dalian 116000,China)

机构地区：[1]大连大学环境与化学工程学院,辽宁大连116000

出　　处：《化学研究与应用》2020年第11期2108-2112,共5页Chemical Research and Application

摘　　要：4-硫胸苷化合物具有很好的抗肿瘤活性,在紫外光辅助下用于治疗癌症。胸苷化合物的硫代反应,在P2S5-Lawesson试剂协同作用下,显著地提高了4-硫核苷类化合物的合成效率,在最佳条件下极大的缩短了反应时间和提高了产率,产物结构用1H NMR及13C NMR进行了表征。4-Thiothymidine compounds have good antitumor activity and are used in the treatment of cancer assisted by ultraviolet light.Under the synergistic effect of P2S5-Lawesson reagent,the thio reaction of thymidine compounds significantly improved the synthesis efficiency of 4-thionucleosides,greatly shortened the reaction time and improved the yields under the optimal conditions.The structure of 4-thionucleosides were characterized by 1H NMR and 13C NMR.

关 键 词：4-硫核苷类化合物 P2S5试剂 LAWESSON试剂 合成 抗肿瘤活性 

分 类 号：O626.4[理学—有机化学]