脑血管介入术在颅内未破裂动脉瘤中应用价值及对afamin与基质金属蛋白酶9血清含量的影响  

The application value of cerebrovascular intervention in unruptured intracranial aneurysms and the effect on the serum levels of afamin and matrix metalloproteinase⁃9

作　　者：王颍超 刘磊[1] 王晨雨[2] 王琨[1] WANG Yingchao;LIU Lei;WANG Chenyu;WANG Kun(Department of Intervention,Zhengzhou People’s Hospital,Zhengzhou,Henan 450000,China;Department of Ultrasound,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州人民医院介入科,河南郑州450000 [2]郑州大学第二附属医院超声科,河南郑州450000

出　　处：《安徽医药》2020年第12期2505-2508,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的研究脑血管介入术在颅内未破裂动脉瘤中应用价值及对血清人类血浆糖蛋白afamin与基质金属蛋白酶9(MMP⁃9)含量的影响。方法选取2015年10月至2018年10月郑州人民医院266例颅内未破裂动脉瘤病人作为研究对象,按随机数字表法分为研究组、对照组,各133例。对照组采取开颅夹闭术,研究组采取脑血管介入术。统计两组住院费用及住院时间、术前及术后afamin与血清MMP⁃9含量、日常生活能力(ADL)及生活质量(SF⁃36)分值,术后随访6个月,统计两组预后效果。结果两组住院费用间差异无统计学意义(P>0.05),研究组住院时间(10.29±3.01)d短于对照组(15.14±2.96)d(P<0.05);术后第2天两组血清afamin含量较术前升高,且研究组(59.56±10.33)μg/L高于对照组(50.53±9.45)μg/L(P<0.05);术后第2天两组血清MMP⁃9含量较术前降低,且研究组(448.67±49.43)ng/L低于对照组(509.45±53.61)ng/L(P<0.05);术后1个月两组SF⁃36、ADL分值较术前增高,且研究组高于对照组(P<0.05);术后随访6个月,研究组预后效果优于对照组(P<0.05)。结论脑血管介入术应用于颅内未破裂动脉瘤中可明显缩短住院时间,提高血清afamin含量,降低血清MMP⁃9含量,改善预后效果,提高日常生活能力及生活质量,且经济效益良好。Objective To study the application value of cerebrovascular intervention in unruptured intracranial aneurysms and the effect on serum human plasma glycoprotein afamin and matrix metalloproteinase 9(MMP⁃9)levels.Methods From October 2015 to October 2018,266 patients with unruptured intracranial aneurysms from Zhengzhou People’s Hospital were selected as the re⁃search objects,and were assigned into study group and control group according to the random number table method,with 133 cases in each group.The control group was treated with craniotomy and clipping,and the study group was treated with cerebrovascular in⁃tervention.The cost of hospitalization and hospital stay,preoperative and postoperative afamin and serum MMP⁃9 levels,activity of daily living(ADL)and quality of life(SF⁃36)scores were calculated for the two groups.The patients were followed up for 6 months after surgery,and the prognostic effects of the two groups were evaluated.Results There was no significant difference in hospital⁃ization expenses between the two groups(P>0.05).The length of hospital stay in the study group was(10.29±3.01)days,shorter than that of the control group[(15.14±2.96)days,P<0.05].On the second day after surgery,the serum afamin levels of the two groups were higher than those before operation,and the level of the study group[(59.56±10.33)μg/L]was higher than that of the control group[(50.53±9.45)μg/L,P<0.05].On the second day after operation,the serum MMP⁃9 levels in the two groups were lower than those before operation,and the level in the study group[(448.67±49.43)ng/L]was lower than that in the control group[(509.45±53.61)ng/L,P<0.05].The SF⁃36 and ADL scores of the two groups were higher than those before the operation one month after operation,and the study group was higher than the control group(P<0.05).The prognostic effect of the study group was better than that of the control group after 6 months of follow⁃up(P<0.05).Conclusion The application of cerebrovascular in⁃tervention to unruptured

关 键 词：颅内动脉瘤 栓塞 治疗性 血管外科手术 糖蛋白类 脑血管介入术 人维生素E结合糖蛋白afamin 基质金属蛋白酶9 预后 

分 类 号：R651.12[医药卫生—外科学]