肾衰宁胶囊联合包醛氧淀粉治疗慢性肾功能衰竭患者的临床研究  

Effect of Shenshuaining capsule combined with coated aldehyde oxystarch on renal function and fibrosis in patients with chronic renal failure

作　　者：李永伟 李慧 陈婧 刘新华 LI Yong-wei;LI Hui;CHEN Jing;LIU Xin-hua(Hemodialysis Room Qingdao Hospital of Traditional Chinese Medicine,Qingdao Hiser Hospital,Qingdao 266033,Shandong Province,China;Department of Nephrology,Qingdao Hospital of Traditional Chinese Medicine Qingdao Hiser Hospital,Qingdao 266033,Shandong Province,China)

机构地区：[1]青岛市中医医院、市海慈医院血透室,山东青岛266033 [2]青岛市中医医院、市海慈医院肾病科,山东青岛266033

出　　处：《中国临床药理学杂志》2020年第21期3429-3432,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察肾衰宁胶囊联合包醛氧淀粉对慢性肾功能衰竭(CRF)患者肾功能及纤维化指标的影响。方法将86例CRF患者,随机分为对照组和试验组,各43例。2组均给予基础治疗。对照组给予包醛氧淀粉,每次5 g,每天3次,口服;试验组在对照组的基础上给予肾衰宁胶囊,每次1.75 g,每天3次。2组均治疗3个疗程。比较2组的临床疗效,比较治疗前后2组肾功能及纤维化相关指标的变化。结果治疗后,试验组和对照组的总有效率分别为86.05%,62.79%,差异有统计学意义(P<0.05)。治疗后,对照组与试验组血尿素氮(BUN)含量分别为(12.01±4.96),(8.03±3.67)mmol·L-1;血肌酸酐(Scr)含量分别为(230.01±33.19),(171.21±30.28)μmol·L-1;肌酸酐清除率(Ccr)分别为(38.49±5.33),(45.01±5.22)mL·min-1;Ⅲ型前胶原(PC-Ⅲ)含量分别为(166.12±47.13),(139.96±43.21)ng·mL-1;Ⅳ型胶原(C-Ⅳ)含量分别为(138.97±39.78),(120.03±33.56)ng·mL-1;纤维粘连蛋白(FN)含量分别为(171.25±33.04),(189.57±34.01)mg·L-1;层粘连蛋白(LN)含量分别为(151.25±39.46),(133.02±36.32)ng·mL-1,差异均有统计学意义(均P<0.05)。对照组胃部不适2例,恶心、呕吐2例,腹泻1例,腹痛1例,药物不良反应总发生率为13.95%(6例/43例);试验组胃部不适1例,恶心、呕吐1例,腹泻1例,药物不良反应总发生率为6.98%(3例/43例),差异无统计学意义(P>0.05)。结论肾衰宁胶囊联合包醛氧淀粉治疗可明显改善CRF患者肾功能,抑制肾纤维化进展,临床疗效确切。Objective To explore the effect of Shenshuaining capsule combined with coated aldehyde oxystarch on renal function and fibrosis in patients with chronic renal failure(CRF).Methods A total of 86 cases of CRF patients were randomly divided into control group(n=43)and treatment group(n=43).Two groups were given basic treatment,control group was orally given coated aldehyde oxystarch,5 g·time-1,3 times·d-1;treatment group was orally given Shenshuaining capsule,1.75 g·time-1,3 times·d-1 on the basis of control group.Two groups were treated for 3 courses.The clinical effect in two groups were compared,the change of relevant indicators about renal function and renal fibrosis in two groups before and after treatment were compared.Results After treatment,the total effective rates in treatment group and control group were 86.05%,62.79%,with significant difference(all P<0.05).After treatment,the blood urea nitrogen(BUN)in control group and treatment group were(12.01±4.96),(8.03±3.67)mmol·L-1;serum creatinine(Scr)were(230.01±33.19),(171.21±30.28)μmol·L-1;creatinine clearance rate(Ccr)were(38.49±5.33),(45.01±5.22)mL·min-1;procollagen typeⅢ(PC-Ⅲ)were(166.12±47.13),(139.96±43.21)ng·mL-1;collagen typeⅣ(C-Ⅳ)were(138.97±39.78),(120.03±33.56)ng·mL-1;fiber adhesion protein(FN)were(171.25±33.04),(189.57±34.01)mg·L-1;laminin(LN)contents were(151.25±39.46),(133.02±36.32)ng·mL-1,all with singnificant difference(all P<0.05).In control group,there were 2 cases of stomach discomfort,2 cases of nausea and vomiting,1 case of diarrhea,and 1 case of abdominal pain,the incidence of adverse drug reactions was 13.95%(6 cases/43 cases);there were 1 case of stomach discomfort,1 case of nausea and vomiting,1 case of diarrhea in treatment group,the incidence of adverse drug reactions was 6.98%(3 cases/43 cases),there was no significnat difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Shenshuaining capsule combined with coated aldehyde oxystarch can significantly improve

关 键 词：慢性肾功能衰竭 肾衰宁胶囊 包醛氧淀粉 肾功能 纤维化 

分 类 号：R28[医药卫生—中药学]