缺血性脑卒中后血脑屏障损伤机制研究现状  

Currents situation of blood-brain barrier dysfunction after ischemic stroke

作　　者：李文倩 吕鹤群 彭拥军[1] 徐疏影 吴旭[1] LI Wen-qian;Lv He-qun;PENG Yong-jun;XU Shu-ying;WU Xu(Department of Acupuncture and Rehabilitation,Jiangsu Province Hospital of Chinese Medicine,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu Province,China;Department of Acupuncture and Neurology,Hospital of Traditional Chinese Medicine of Yancheng,Yancheng 224001,Jiangsu Province,China)

机构地区：[1]江苏省中医院针灸康复科、南京中医药大学附属医院,江苏南京210029 [2]盐城市中医院针灸脑病科,江苏盐城224001

出　　处：《中国临床药理学杂志》2020年第21期3533-3537,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81973932,81574060,81001556);第六批全国老中医药专家学术经验继承人基金资助项目(国家中医药管理局,国中医药人教发[2017]29号);中国博士后科学基金资助项目(2015M571790)。

摘　　要：血脑屏障(blood brain barrier,BBB)是大脑和外周循环之间的重要屏障,通过严密调节物质交换在维持中枢系统内环境稳态中起着至关重要的作用。缺血性脑卒中(ischemic stroke,IS)可引起BBB损伤及破坏,进一步促进缺血性脑损伤的发展。本文总结并归纳了IS后引起BBB损伤及功能障碍的相关分子及细胞机制,有望为发现潜在的治疗靶点提供线索,以保护BBB并改善IS患者预后。Blood-brain barrier(BBB)is an essential barrier between the peripheral circulation and the brain.It plays a vital role in maintaining the homeostasis of brain microenvironment via regulating the exchange of substances.During and after ischemic stroke(IS),BBB disruption facilitates injury progression.This article reviews recent advances in cellular and molecular mechanisms underlying BBB dysfunction after ischemic stroke through retrieving relevant literatures,which reveals promising potential therapeutic targets for protecting the BBB and improving patient outcomes after ischemic stroke.

关 键 词：缺血性脑卒中 血脑屏障 内皮细胞 星形胶质细胞 周细胞 

分 类 号：R972[医药卫生—药品]