比索洛尔联合替米沙坦治疗房颤的临床效果及对肿瘤坏死因子、IL-6的影响  

Clinical Effect of Bisoprolol Combined with Telmisartan in the Treatment of Atrial Fibrillation and Its Effect on Tumor Necrosis Factor and IL-6

作　　者：赖文文 林娜萍 张志龙 许朝祥[1] 蔡克锋[1] 卢辉耀[1] LAI Wenwen;LIN Naping;ZHANG Zhilong;XU Chaoxiang;CAI Kefeng;LU Huiyao(The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;不详)

机构地区：[1]福建医科大学附属第二医院,福建泉州362000

出　　处：《中外医学研究》2020年第31期47-49,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究比索洛尔联合替米沙坦治疗房颤的临床效果及对肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)的影响。方法:选取2016年1月-2018年1月笔者所在医院收治的300例房颤患者作为研究对象,采用双色球法将其分为对照组和观察组,每组150例。对照组采用比索洛尔治疗,观察组采用比索洛尔联合替米沙坦治疗。比较两组临床疗效、TNF-α、IL-6水平、房颤发作频率、发作持续时间、复发情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组TNF-α、IL-6水平均低于对照组,差异有统计学意义(P<0.05)。观察组房颤发作频率低于对照组,发作持续时间短于对照组,差异均有统计学意义(P<0.05)。观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论:比索洛尔联合替米沙坦治疗房颤的临床效果显著,可降低炎性因子水平及房颤发作频率,缩短发作持续时间,复发率低。Objective:To investigate the clinical effect of Bisoprolol combined with Telmisartan in the treatment of atrial fibrillation and its effect on tumor necrosis factor(TNF-α)and interleukin-6(IL-6).Method:A total of 300 patients with atrial fibrillation admitted in our hospital from January 2016 to January 2018 were selected as the study subjects and were divided into the control group and the observation group by the double chromosphere method,with 150 patients in each group.The control group was treated with Bisoprolol,and the observation group was treated with Bisoprolol combined with Telmisartan.The clinical effect,TNF-α and IL-6 levels,frequency of atrial fibrillation attack,duration of attack,and recurrence were compared between the two groups.Result:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of TNF-α and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The frequency of atrial fibrillation attack in the observation group was lower than that in the control group,and the duration of attack was shorter than that in the control group,and the differences were statistically significant(P<0.05).The recurrence rate of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion:The clinical effect of Bisoprolol combined with Telmisartan in the treatment of atrial fibrillation is remarkable,which can reduce the level of inflammatory factors and the frequency of atrial fibrillation attack,shorten the duration of attack.The recurrence rate is low.

关 键 词：比索洛尔 替米沙坦 房颤 临床效果 肿瘤坏死因子 白细胞介素-6 复发率 

分 类 号：R541.75[医药卫生—心血管疾病]