2012—2018年某肿瘤医院铂类药物不良反应分析  

Analysis of Adverse Reactions of Platinum Drugs in a Cancer Hospital from 2012 to 2018

作　　者：李梦霞 郭芷汛 刘欢 田小燕 李艳[1] 满智能 李刚[1] LI Mengxia;GUO Zhixun;LIU Huan;TIAN Xiaoyan;LI Yan;MAN Zhineng;LI Gang(Department of Pharmacy, Sichuan Provincial People's Hospital, Chengdu 610072, China;Clinical Research Center, Sichuan Cancer Hospital, Chengdu 610041, China;Department of Pharmacy, Sichuan Provincial Department of Transportation, Highway Bureau Hospital, Chengdu 611731, China;West China College of Pharmacy, Sichuan University, Chengdu 610041,China)

机构地区：[1]四川省人民医院药学部,成都610072 [2]四川省肿瘤医院临床研究中心,成都610041 [3]四川省交通运输厅公路局医院药剂科,成都611731 [4]四川大学华西药学院,成都610041

出　　处：《医药导报》2020年第12期1750-1754,共5页Herald of Medicine

基　　金：四川省卫计委重点研究基金资助资助项目(16ZD030);四川省交通厅局级课题资助项目(2017-07);成都药学会赞邦药学科研基金资助项目(201920);成都药学会赞邦药学科研基金资助项目(201915)。

摘　　要：目的分析某肿瘤医院2012—2018年铂类药物不良反应(ADR)的发生规律和特点,探讨ADR发生原因,为临床合理应用药提供参考。方法采用回顾性分析方法,对该院2012—2018年上报的404例铂类ADR进行信息汇总,分别从患者基本情况、药品名称、原患疾病、ADR发生时间、累及器官或系统、ADR严重程度及转归情况进行统计分析,并通过数据挖掘方法分析ADR相关因素的关联情况。结果ADR报告中,41~50岁患者比例最高;顺铂所致ADR例数最多;含铂化疗方案最常见的ADR是骨髓抑制;51.83%的ADR发生在用药几天后。顺铂与血液系统及胃肠系统损害关联较强;洛铂与血液系统损害关联较强;ADR发生时间为2~10 d与血液系统损害关联较强;关联规则显示:1~24 h内发生的ADR与奥沙利铂所致ADR严重程度较低。结论医护人员在日常临床工作中,应重视ADR信息上报,总结不同ADR的发生规律及特点,给出合理的监护建议,减少ADR的发生,保障患者用药安全。Objective To analyze the occurrence regularity and characteristics of platinum-based adverse drug reactions(ADR)in a cancer hospital from 2012 to 2018,and to explore the causes of ADR,so as to provide references for clinical rational application of drugs.Methods A retrospective analysis method was used to summarize the information on 404 cases of platinum-based ADR reported in the hospital from 2012 to 2018.Statistical analysis was performed from the basic condition of the patient,drug names,the original disease,the time of ADR,the organ or system involved,the severity and the outcome of ADR.The data mining method was used to analyze the correlation of ADR related factors.Results In the ADR report,the proportion of patients aged 41-50 was the highest;the number of ADR cases was the highest in cisplatin;the most common ADR in platinum-containing chemotherapy regimens was myelosuppression;51.83%of ADR occurred several days after the administration.Cisplatin is closely related to the damage of blood system and gastrointestinal system;Lobaplatin has a strong correlation with blood system damage;ADR occurred within 2-10 d,which was strongly associated with blood system damage;the association rules show that the severity of ADR which occurred within 1-24 h or caused by oxaliplatin was low.Conclusion In daily clinical work,medical staff should pay attention to ADR information reporting,summarize the regularity and characteristics of different ADR occurrences,give reasonable monitoring advice,reduce the occurrence of ADR and ensure the safety of patients'medication.

关 键 词：铂类药物 药品不良反应 用药安全 

分 类 号：R979.1[医药卫生—药品] R969.3[医药卫生—药学]