过敏性鼻炎患者血清中炎症因子、免疫球蛋白及T淋巴细胞亚群水平检测及分析  

Detection and analysis of serum inflammatory factors,immunoglobulin and T lymphocyte subsets in patients with allergic rhinitis

作　　者：鲍千红 吕凌云[2] 张伟群 张一超 BAO Qian-hong;LV Ling-yun;ZHANG Wei-qun;ZHANG Yi-chao(Clinical Laboratory,the First People's Hospital of Lin'an District,Hangzhou,Zhejiang 311300,China;不详)

机构地区：[1]杭州市临安区第一人民医院检验科,浙江杭州311300 [2]杭州市中医院检验科,浙江杭州310005

出　　处：《中国卫生检验杂志》2020年第21期2614-2616,共3页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医药卫生科技计划项目(2017KY569)。

摘　　要：目的探讨过敏性鼻炎(allergicrhinitis,AR)患者血清中炎症因子、免疫球蛋白及T淋巴细胞亚群水平的变化。方法收集2017年5月-2018年5月本院收治的过敏性鼻炎患者60例为观察组,其中30例为持续性组,30例为间歇性组;同期于本院体检的健康志愿者60例为对照组。检测各组患者血清中C-反应蛋白(CRP)、白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、免疫球蛋白A(Ig A)、免疫球蛋白E(Ig E)、免疫球蛋白G(Ig G)、CD3^+、CD4^+、CD8^+水平,并计算CD4^+/CD8^+比值。结果观察组患者血清中CRP、IL-4及TNF-α水平明显高于对照组;持续性组患者血清中CRP、IL-4、TNF-α水平明显高于间歇性组,差异均有统计学意义(P<0.05)。观察组患者血清中Ig A、Ig G水平明显低于对照组,Ig E水平明显高于对照组;持续性组患者血清中Ig A、Ig G水平明显低于间歇性组,Ig E水平明显高于间歇性组,差异均有统计学意义(P<0.05)。观察组患者血清中CD3^+、CD4^+水平及CD4^+/CD8^+比值明显低于对照组,差异均有统计学意义(P<0.05)。结论AR会导致患者体内炎症因子水平紊乱及免疫功能水平降低,且持续性过敏性鼻炎患者上述反应更加明显,免疫球蛋白水平的检测对过敏性鼻炎疾病持续状态判断具有重要意义;可通过提高患者免疫功能,缓解AR患者疾病进展。Objective To investigate the changes of serum inflammatory factors,immunoglobulin and T lymphocyte subsets in patients with allergic rhinitis.Methods Sixty patients with allergic rhinitis were collected in our hospital from May 2017 to May 2018 as the observation group.30 patients were collected as persistent group and 30 patients were collected as intermittent group.60 healthy volunteers in our hospital at the same time were collected as the control group.Serum levels of CRP,IL-4,TNF-α,IgA,IgE,IgG,CD3^+,CD4^+,CD8^+,CD4^+/CD8^+of patients in each group were detected.Results The serum levels of CRP,IL-4 and TNF-αin the observation group were significantly higher than those in the control group.The serum levels of CRP,IL-4 and TNF-αof patients in persistent group were significantly higher than those in intermittent group,and the difference was statistically significant(P<0.05).The serum levels of IgA and IgG of patients in the observation group were significantly lower than that in the control group,and the IgE level was significantly higher than that in the control group(P<0.05).The serum levels of IgA and IgG of patients in persistent group was significantly lower than that in the intermittent group,and the level of IgE was significantly higher than that in the intermittent group,and the difference was statistically significant(P<0.05).The levels of CD3^+,CD4^+and CD4^+/CD8^+in the serum of patients in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion AR can lead to the disorder of inflammatory factors and the decrease of immune function in patients,and the above reaction is more obvious in patients with persistent allergic rhinitis,and detection of immunoglobulin levels is of great significance for the diagnosis of persistent condition of allergic rhinitis.By improving the immune function of patients,the disease progression of AR can be alleviated.

关 键 词：过敏性鼻炎 炎症因子 免疫球蛋白 T淋巴细胞亚群 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]