甲状腺相关眼病的泪液标志物及其临床意义  

The tear biomarkers in thyroid associated ophthalmopathy and its clinical significance

作　　者：鲁奕(综述) 周慧芳(审校)[1] Lu Yi;Zhou Huifang(Department of Ophthalmology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院眼科,200011

出　　处：《中华实验眼科杂志》2020年第11期993-996,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家重点研发计划项目(2018YFC1106100);国家自然科学基金面上项目(81770960);国家自然科学基金国际(地区)合作与交流项目(81761168037);上海市科学技术委员会项目(17DZ2260100);上海市教委“高水平地方高校建设创新团队”眼肿瘤与眼眶修复协同创新团队项目(SSMU-ZDCX20180410);上海交通大学医学院附属第九人民医院院级基金项目(JYHL2019MS04)。

摘　　要：甲状腺相关眼病(TAO)是成年人最常见的眼眶疾病。临床上TAO的眼表损害症状常见且危害大,主要包括结膜充血、水肿、干眼以及暴露性角膜炎等,严重者可引起角膜溃疡,甚至因角膜穿孔而致盲。多项研究表明,TAO患者泪腺体积增大,泪腺组织变性,其分泌的泪液成分发生改变,特别是甲状腺相关蛋白及炎性因子浓度上升,这些因素可能是导致TAO眼表损害的关键因素。分析TAO患者的泪液标志物改变有助于疾病的分期和治疗,同时可以作为鉴别诊断的依据之一。本文就TAO患者的泪液标志物种类及其临床意义进行综述。Thyroid associated ophthalmopathy(TAO)is the most common orbital disease in the clinic.The ocular surface damage in TAO can be commonly seen and does great harm to visual function,which includes conjunctival congestion,edema,dry eye and exposure keratitis.Several cases can cause corneal ulcers,and even corneal perforation and blindness.Many studies have shown that the increase of lacrimal gland volume,the pathological changes of lacrimal gland tissue and the changes of tear secretion and composition especially the increase of inflammatory factors can be seen in TAO patients.These are key factors for TAO-related ocular surface damage.The analysis of the changes in the tear biomarkers of TAO patients is helpful for the staging and treatment of the disease,and can be used as one of the indicators of the differential diagnosis.This article reviews the types and clinical significance of tear biomarkers in TAO patients.

关 键 词：甲状腺相关眼病 泪液标志物 眼表损害 

分 类 号：R581[医药卫生—内分泌] R771.3[医药卫生—内科学]