三七提取物在心血管疾病临床应用中的研究进展  

Recent Advances in Clinical Application of Panax Notoginseng Saponins in Cardiovascular Diseases

作　　者：卢淑立 冯妍[1] 高杰[1] 靳相公 王以新[1] 陈可冀[3] LU Shuli;FENG Yan;GAO Jie;JIN Xianggong;WANG Yixin;CHEN Keji(Department of General Medicine,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Department of Community Health,Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China;Department of Cardiovascular Medicine,Xiyuan Hospital China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]首都医科大学附属北京安贞医院全科医疗科,北京市100029 [2]北京中医药大学第三附属医院社区中心,北京市100029 [3]中国中医科学院西苑医院心血管科,北京市100091

出　　处：《中国全科医学》2021年第5期539-545,共7页Chinese General Practice

基　　金：国家自然科学基金资助项目(81703932);医管局青苗人才基金资助项目(QML20190605);北京市中医药管理局科技发展资金项目(JJ-2020-01)。

摘　　要：三七作为我国传统中药,因其具有活血化瘀的功效,在治疗心血管疾病方面疗效显著,且随着现代中药提取技术的提高,三七提取物极大程度地提高了其作用功效。整理近几年国内外关于三七提取物(主要成分为三七总皂苷)在治疗心血管疾病(冠心病、高血压、心力衰竭、心律失常)时的作用机制、临床应用效果及可能的不良反应等文献,并对所查阅的相关文献进行相应的剖析、归纳及总结。本文结论为三七提取物三七总皂苷及其有效成分对治疗心血管疾病有明确疗效,尤其是在冠心病、高血压、心力衰竭、心律失常或多种疾病同时合并存在时,三七提取物三七总皂苷可起到使用单一药物而发挥多种药效的作用,同时减轻患者经济及精神压力,提高患者生活质量。Panax notoginseng is a traditional Chinese medicine that has a significant effect on cardiovascular diseases for its effect of promoting blood circulation and removing blood stasis.With the development of techniques for extracting herb drugs,improved purity of Panax notoginseng extract greatly improves its efficacy.In this paper,we reviewed recent literature concerning Panax notoginseng extract〔with Panax notoginseng saponins(PNS)as the main component〕in the treatment of cardiovascular diseases(coronary heart disease,hypertension,heart failure,arrhythmia),and analyzed and summarized the mechanism of action,clinical effect and possible adverse reactions of PNS,and concluded that PNS and its active ingredients have definite curative effects on cardiovascular diseases.Moreover,PNS may produce a variety of pharmacodynamic effects on coronary heart disease,hypertension,heart failure,arrhythmia or coexisting cardiovascular diseases,thereby reducing the economic and mental pressures and improving quality of life of the patients.

关 键 词：心血管疾病 三七 三七总皂苷 三七皂甙 心血管药物(中药) 

分 类 号：R54[医药卫生—心血管疾病]