小剂量阿司匹林肠溶片联合拉贝洛尔在妊娠期高血压患者中的应用效果  

Application Effect of Low-dose Aspirin Enteric-coated Tablets Combined with Labelol in the Treatment of Hypertensive Patients in Pregnancy

作　　者：郝敏 HAO Min(Dalian Maternal and Child Health Hospital,Dalian 116083,China)

机构地区：[1]大连市妇幼保健院,辽宁大连116083

出　　处：《中国医药指南》2020年第30期57-58,共2页Guide of China Medicine

摘　　要：目的分析小剂量阿司匹林肠溶片联合拉贝洛尔在妊娠期高血压患者中的应用效果。方法选取2019年7月至2020年4月大连市妇幼保健院收治的86例妊娠期高血压患者,随机将其分为观察组和对照组,各43例。对照组采取拉贝洛尔治疗,观察组给予小剂量阿司匹林肠溶片+拉贝洛尔治疗,比较两组患者的治疗效果、血压水平、凝血功能及妊娠结局。结果观察组治疗总有效率高于对照组(P<0.05);观察组血浆凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、血浆凝血酶时间(TT)水平均高于对照组(P<0.05);观察组收缩压水平、血浆纤维蛋白原(Fib)水平、D二聚体(D-D)水平、舒张压水平低于对照组(P<0.05)。观察组不良妊娠结局发生率低于对照组(P<0.05)。结论小剂量阿司匹林肠溶片+拉贝洛尔治疗妊娠期高血压的效果良好,可使患者凝血功能显著改善,血压水平明显降低,有助于降低不良妊娠结局。Objective To analyze the eff ect of low-dose aspirin enteric-coated tablets combined with labelol on the treatment of hypertensive patients in pregnancy and the infl uence on the coagulation function.Methods A total of 86 patients with hypertension during pregnancy admitted to Dalian Maternal and Child Health Hospital from July 2019 to April 2020 were randomly divided into observation group and control group,with 43 cases in each group.The control group was treated with labetalol,and the observation group was given low-dose aspirin enteric-coated tablets+labetalol.To compare the treatment eff ect,blood pressure level,coagulation function and pregnancy outcome of the two groups.Results The total eff ective rate of treatment in the observation group was higher than that in the control group(P<0.05);the plasma prothrombin time(PT),activated partial thromboplastin time(APTT),and plasma thrombin time(TT)levels in the observation group were higher than those in the control group(P<0.05).The systolic blood pressure,plasma fi brinogen(Fib)level,D-dimer(DD)level,and diastolic blood pressure level of the observation group were lower than those of the control group(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group(P<0.05).Conclusion Low-dose aspirin enteric-coated tablets+labetalol have a good eff ect on the treatment of hypertension during pregnancy,which can signifi cantly improve the blood coagulation function of patients,signifi cantly reduce blood pressure levels,and help reduce adverse pregnancy outcomes.

关 键 词：妊娠期高血压 凝血功能 剂量学 血压 妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]