微波促进下三氟甲基芴酮类化合物的合成研究  

Synthesis of Trifluoromethylation Fluorenones Compound under Microwave Irradiation

作　　者：牛腾 杨天宇[2] 魏惠荣 张亚婷 刘琦敏 郭昊岩 NIU Teng;YANG Tian-yu;WEI Hui-rong;ZHANG Ya-ting;LIU Qi-min;GUO Hao-yan(School of Chemical Engineering,Lanzhou University of Arts and Science,Lanzhou 730000,China;School of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730000,China)

机构地区：[1]兰州文理学院化工学院,甘肃兰州730000 [2]西北师范大学化学化工学院,甘肃兰州730070

出　　处：《兰州文理学院学报（自然科学版）》2020年第6期51-55,共5页Journal of Lanzhou University of Arts and Science(Natural Sciences)

基　　金：甘肃省教育厅高等学校创新基金项目(2020B-253);甘肃省教育厅高等教育教学成果培育项目;甘肃省大学生创新创业训练计划项目(S202011562030);国家自然科学基金项目(21662030)。

摘　　要：芴酮骨架广泛存在于具有生物活性的天然产物中,在药物化学和材料化学领域中被广泛用作核心结构单元.以三氟甲基吡啶为底物,通过微波辐射的方法高产率地合成了芴酮类化合物,其产物结构经熔点、核磁共振谱(13 C NMR、1 H NMR)及高分辨质谱予以确证.该方法具有反应时间短、收率高、操作简单等优点.Fluorenones compounds were widely found in bioactive natural products and served as core structure unit in the research of pharmaceutical chemistry and material chemistry.In this article,trifluoromethylpyridines was used as substrate for synthesis of fluorenones by microwave irradiation.The structures of the products were identified by IR,NMR(13 C NMR、1H NMR),and HRMS spectra.This new procedure had the advantages of short reaction time,high yields,and simple operation as well as environmental friendliness.

关 键 词：三氟甲基 芴酮 微波 合成 

分 类 号：O621.3[理学—有机化学]