维生素D水平与2型糖尿病关系的meta分析  

The meta analysis of relationship between the level of vitamin D and type 2 diabetes mellitus

作　　者：郭逸星 吴丹 吴清锋 李思思[1] 黄争春[3] 李剑[3] 董明华[1] GUO Yi-xing;WU Dan;WU Qing-fen;LI Si-si;HUANG Zheng-chun;LI Jian;DONG Ming-hua(School of Public Health and Health Management,Gannan Medical University,Ganzhou,Jiangxi 341000;Zhoujiadu Community Health Service Center,Pudong District,Shanghai 200120;Department of Anatomy,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院预防医学系流行病学教研室,江西赣州341000 [2]上海市浦东新区周家渡社区卫生服务中心,上海200120 [3]赣南医学院解剖教研室,江西赣州341000

出　　处：《赣南医学院学报》2020年第10期1061-1067,共7页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(81550045);江西省自然科学基金项目(20171BAB205073)。

摘　　要：目的:通过系统评价维生素D与2型糖尿病患者血糖代谢相关指标的相关性,探索维生素D水平与2型糖尿病之间的关系。方法:检索中国知网、万方数据库、PubMed等数字资源库,检索时间从建库至2018年3月,选择研究类型为横断面研究及病例对照研究文献,根据文献纳排标准,摘录相关数据,采用Stata统计软件进行meta分析。结果:最终纳入27篇文献,meta分析结果表明,维生素D与空腹血糖、糖化血红蛋白、胰岛β细胞功能、胰岛素抵抗均存在显著的相关性(r1=-0.28,r2=-0.23,r3=0.38,r4=-0.14;P<0.001)。结论:血清维生素D水平与糖代谢若干指标存在负相关性,提高维生素D水平可能有助于血糖控制。Objective:This systematic review and meta-analysis aimed to explore the relationship between the level of Vitamin D and Type 2 Diabetes Mellitus through correlation analysis.Methods:TSystematic literature review was performed using digital resource databases including China National Knowledge Infrastructure(CNKI),Wanfang database and Pubmed to search for relevant articles published before March 2018.Cross-sectional study and case control study that compare the level of Vitamin D and Type 2 Diabetes Mellitus were assessed and the related data based on document inclusion criteria were extracted.Stata statistical software was used to perform the meta-analysis.Results:27 studies were included in the meta-analysis and revealed that Vitamin D is correlated with fasting blood-glucose(FBG),glycosylated hemoglobin,beta-cell function and insulin resistance(r1=-0.28,r2=-0.23,r3=0.38,r4=-0.14;P<0.001).Conclusion:There was a negative correlation between serum vitamin D level and some indicators of glycometabolism.Developing the level of vitamin D is beneficial of glycemic control.

关 键 词：维生素D 2型糖尿病 相关性研究 META分析 

分 类 号：R195.4[医药卫生—卫生统计学]