m^6A甲基化与代谢性疾病的研究进展  

Research advances of m^6A methylation and metabolic disease

作　　者：钟慧 卿即娜 尹凯 ZHONG Hui;QING Ji’na;YIN Kai(Research Laboratory of Translational Medicine,Hengyang Medical School,University of South China&Hengyang Medical School,University of South China,Hengyang 421001,China;Department of Stomatology,School of Stomatology,Changsha Medical College,Changsha,Hunan 410200,China;the Second Affiliated Hospital of Guilin Medical University&Guangxi Key Laboratory of Diabetic Systems Medicine&Guilin Medical University,Guilin,Guangxi 541000,China)

机构地区：[1]南华大学衡阳医学院转化医学研究室南华大学衡阳医学院,湖南省衡阳市421001 [2]长沙医学院口腔医学院口腔基础教研室,湖南省长沙市410200 [3]桂林医学院第二附属医院广西糖尿病系统医学重点实验室桂林医学院,广西桂林市541000

出　　处：《中国动脉硬化杂志》2020年第11期1002-1008,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(81970390,81470569);湖南省自然科学基金(2018JJ2341);国家级大学生创新创业训练计划资助项目(201710555015,201710555010)。

摘　　要：N6-甲基腺嘌呤(N6-methyladenosine,m^6 A)是腺嘌呤(A)第6位氮原子被甲基转移酶催化形成的一种RNA甲基化修饰,是真核生物信使RNA(mRNA)上最多的化学修饰形式。近年来研究发现m^6 A对RNA在脂肪组织生成、细胞分化和免疫/炎症反应等过程中发挥重要的调控作用。代谢性疾病是由体内蛋白质、葡萄糖和脂质代谢紊乱引起的一类慢性炎症疾病。在肥胖、2型糖尿病和心血管疾病等代谢性疾病的发生发展中,m^6 A甲基化修饰通过调控糖脂代谢和免疫/炎症发挥着重要角色。文章拟对m^6 A甲基化在代谢性疾病中的作用做一综述,并从表观转录组学的角度为代谢性疾病的防治提供新的思路。m^6 A methyladenosine is a methylation modification catalyzed by methyltransferase at the 6th position nitrogen atom of adenine(A),which is the most common chemical modification on eukaryotic messenger RNA(mRNA).Recently,m^6 A has been found to play an important role in the dynamic regulation of RNA,which is crucial for the basic physiological processes such as adipogenesis,cell differentiation and immune/inflammatory response.Metabolic diseases are series of disorders caused by metabolic dysfunction of proteins,glucose and lipid in the body.The studies have shown that m^6 A methylation plays a key role in the development of metabolic diseases such as obesity,type 2 diabetes and cardiovascular diseases via regulation of glucose/lipid metabolism and immune/inflammation.This paper will review the role of m^6 A methylation in metabolic diseases,which may provide new ideas for the prevention and treatment of metabolic diseases from the perspective of epitranscriptome.

关 键 词：m^6 A甲基化 代谢性疾病 肥胖 2型糖尿病 心血管疾病 

分 类 号：R541[医药卫生—心血管疾病]