心外膜脂肪含量与冠心病的相关性研究  

Associations between epicardial adipose tissue volume and coronary heart disease

作　　者：周自强[1] 吴明营[1] 张龙飞 崔华楠 王妍军[1] 吴文波 ZHOU Ziqiang;WU Mingying;ZHANG Longfei;CUI Huanan;WANG Yanjun;WU Wenbo(Cardiovascular Center of Beijing Tongren Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞同仁医院心外科,100730 [2]邢台市人民医院心外科

出　　处：《心肺血管病杂志》2020年第11期1342-1345,共4页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:评价心外膜脂肪组织(EAT)体积与冠心病的相关性。方法:入选2013年1月1日至2015年6月30日在北京同仁医院接受冠状动脉CT成像(CTA)检查及冠状动脉造影检查的患者进行回顾性分析。将患者根据冠状动脉造影结果分为冠心病组和非冠心病组。采用256层螺旋CT定量测量EAT体积。同时收集患者一般临床资料、BMI、超声心动相关指标、以及血糖、血脂、肝功能等生化指标。采用多因素logistic回归分析包括EAT在内的多种因素与冠心病的相关性。结果:共入选病例118例,其中冠心病组52例,非冠心病组66例。单因素分析显示,冠心病组EAT体积显著高于非冠心病组[(161.59±37.32)vs.(139.51±30.64)cm3,P<0.001]。多因素Logistic回归结果显示年龄(OR=1.117,P=0.027)、BMI(OR=1.221,P=0.033)、高血压病史(OR=1.376,P=0.030)、EAT含量(OR=2.063,P<0.001,)、hs-CRP(OR=1.721,P=0.049)和血清钙离子浓度(OR=1.107,P=0.005)与冠心病显著相关。受试者工作特征(ROC)曲线分析比较EAT与BMI对冠心病的诊断效力,结果显示EAT体积的ROC曲线下面积高于BMI(0.661 vs.0.608,P<0.001)。结论:EAT含量与冠心病显著相关,且相关性可能优于BMI。Objective:To evaluate the correlation between epicardial adipose tissue(EAT)volume and coronary heart disease.Methods:Patients who received coronary CT(CTA)and coronary angiography in Beijing Tongren Hospital between January 1,2013 and June 30,2015 were selected for retrospective analysis.All enrolled Patients were divided into CHD group and non-CHD group according to the result of coronary angiography.The quantitative measurements EAT volume were performed using 256-slice spiral CT for all participants.At the same time,the general clinical data,body mass index,echocardiography related indicators,liver function indicators,levels of blood glucose and lipid,and other biochemical indicators were collected.Multivariate logistic regression was used to analyze the correlation between various factors including EAT and the presence of coronary heart disease.Results:A total of 118 cases were included,including 52 in the CHD group and 66 in the non-CHD group.EAT volume of CHD group was significantly higher than that of non-CHD group[(161.59±37.32)vs.(139.51±30.64)cm3,P<0.001]based on univariate analysis.Multivariable Logistic regression model showed that age(OR=1.117,P=0.027),BMI(OR=1.221,P=0.033),hypertension(OR=1.376,P=0.030),EAT content(OR=2.063,P<0.001),high-sensitivity c-reactive protein levels(OR=1.721,P=0.049)and the serum calcium ion concentration(OR=1.107,P=0.005)were significantly associated with coronary heart disease(CHD).The diagnostic efficacy of EAT volume and BMI for CHD was performed using ROC curve analysis,showing that the area under the ROC curve of EAT volume was higher than BMI(0.661 vs.0.608,P<0.001).Conclusions:EAT content is significantly correlated with coronary heart disease,and the correlation may be better than BMI.

关 键 词：心外膜脂肪 冠心病 体质量指数 冠状动脉CT成像 冠状动脉造影 

分 类 号：R54[医药卫生—心血管疾病]