分泌蛋白SLIT3的生物学作用  

Biological Functions of Secretory Protein SLIT3

作　　者：江凌煜 孙建勋[1] 黄定明[1] JIANG Lingyu;SUN Jianxun;HUANG Dingming(State Key Laboralory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Conservative Dentistry and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,成都市610041

出　　处：《医学分子生物学杂志》2020年第5期397-402,共6页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.81300847)。

摘　　要：SLIT蛋白是一种分泌蛋白,其主要受体是ROBO跨膜蛋白家族,最初在果蝇的中枢神经系统研究中被发现,在神经发育过程中起重要作用.SLIT3是SLIT蛋白家族成员之一,也是一种经典的轴突引导分子.近年来,随着对其研究的不断深入,研究人员发现SLIT3还具有在肿瘤形成过程中抑制癌症发展,以及促进血管生成、偶联骨形成与骨吸收、调节炎症和细胞迁移运动、参与器官发育等广泛的生物学作用,并且正在逐步探索其在临床上的应用.SLIT protein is a secretory protein,and its main receptor is the ROBO transmembrane protein family.It was first found in the research of the central nervous system of Drosophila and have been proved to play an important role in nerve development.SLIT3 is a member of the SLIT protein family and a classical axon-guiding molecule.In recent years,researchers have further found that SLIT3 also possesses a wide range of biological functions,such as inhibiting the development of cancer during tumor formation,promoting angiogenesis,coupling bone formation and bone resorption,regulating inflammation and cell migation,participating in organ development and so on and are exploring its clinical application.

关 键 词：SLIT/ROBO信号通路 SLIT3 生物学作用 

分 类 号：Q71[生物学—分子生物学]