阿仑膦酸钠联合甲氨喋呤治疗绝经后类风湿关节炎患者的疗效研究  

Study on efficacy of alendronate sodium combined with methotrexate in the treatment of postmenopausal patients with rheumatoid arthritis

作　　者：曹赛霞 CAO Sai-xia(Department of Rheumatology and Immunology,People’s Hospital of Inner Mongolia Autonomous Region,Hohhot 010000,China)

机构地区：[1]内蒙古自治区人民医院风湿免疫科,010000

出　　处：《中国实用医药》2020年第32期99-101,共3页China Practical Medicine

摘　　要：目的研究阿仑膦酸钠联合甲氨喋呤治疗绝经后类风湿关节炎患者的疗效。方法 80例绝经后类风湿关节炎患者,以治疗方式不同分为A组和B组,每组40例。A组患者采用常规治疗, B组患者采用阿仑膦酸钠联合甲氨喋呤进行治疗。对比两组患者治疗前后视觉模拟评分法(VAS)评分以及临床治疗效果、不良反应发生情况、生活质量评分。结果 B组的治疗总有效率97.50%明显高于A组的80.00%,差异具有统计意义(P<0.05)。治疗前,两组患者的VAS评分比较差异无统计学意义(P>0.05);治疗后,两组患者的VAS评分均较治疗前下降, B组的下降程度明显大于A组,差异具有统计意义(P<0.05)。B组患者的不良反应发生率10.00%明显低于B组的27.50%,差异具有统计意义(P<0.05)。B组患者的生理功能、躯体疼痛、社会功能、情感职能、精神健康评分均明显高于A组,差异具有统计意义(P<0.05)。结论使用阿仑膦酸钠联合甲氨喋呤对绝经后类风湿关节炎患者进行治疗,可有效提高患者的临床治疗效果,同时还能缓解患者的疼痛,减少不良反应发生率,值得在临床中推广应用。Objective To study the efficacy of alendronate sodium combined with methotrexate in the treatment of postmenopausal patients with rheumatoid arthritis. Methods A total of 80 postmenopausal patients with rheumatoid arthritis were divided into group A and group B according to different treatment methods, with 40 cases in each group. Group A was treated with conventional therapy, and group B was treated with alendronate sodium combined with methotrexate. The visual analogue scale(VAS) score, clinical effect, occurrence of adverse reactions and quality of life score were compared between the two groups. Results The total effective rate of treatment 97.50% of group B was obviously higher than 80.00% of group A, and the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in VAS score between the two groups(P>0.05). After treatment, VAS score of the two groups were lower than those before treatment, and the decrease degree of group B was significantly greater than that of group A, and the difference was statistically significant(P<0.05). The incidence of adverse reactions 10.00% of group B was obviously lower than 27.50% of group B, and the difference was statistically significant(P<0.05). The physiological function, physical pain, social function, emotional function, mental health score of group B were obviously higher than those of group A, and the difference was statistically significant(P<0.05). Conclusion Alendronate sodium combined with methotrexate can effectively improve the clinical treatment effect of postmenopausal patients with rheumatoid arthritis, but also can alleviate the pain of patients and reduce the incidence of adverse reactions, which is worthy of clinical promotion and application.

关 键 词：阿仑膦酸钠 甲氨喋呤 绝经后类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]