中脑腹侧被盖区向岛叶的上行投射通路参与慢性痛信息传递和调控的研究进展  

Research progress on the upward projection pathway from the midbrain ventral tegmen-tal area to the insular cortex involved in pain information transmission and regulation

作　　者：任佳豪 王舰 李辉 李云庆 Ren Jiahao;Wang Jian;Li Hui;Li Yunqing(Department of Human Anatomy,Histology and Embryology,Air Force Medical University,Xi’an 710032,China;Department of Cardiovascular Surgery,General Hospital of Western Command Theater,Chengdu 610083,China)

机构地区：[1]空军军医大学人体解剖与组织胚胎学教研室,西安710032 [2]西部战区总医院心血管外科,成都610083

出　　处：《中国组织化学与细胞化学杂志》2020年第4期369-373,共5页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金(81701115;81620108008)。

摘　　要：中脑腹侧被盖区(VTA)及岛叶(IC)在疼痛中发挥重要作用。急性疼痛刺激信息可以快速调节VTA中的多巴胺(DA)神经元的活性,而持续的慢性痛刺激能降低VTA内DA能神经元的兴奋性。IC前部(AI)和后部(PI)分别与痛情绪的形成和痛信息的感受有关。慢性痛状态下IC会发生可塑性变化,出现突触传递的长时程增强(LTP)效应。VTA-IC上行DA能神经通路可能直接参与人或动物的痛信息的传递和调控。对VTA-IC上行DA能神经通路的研究可能为慢性痛的临床治疗提供新的靶点。The ventral tegmental area(VTA)and insular cortex(IC)of midbrain play important roles in the comorbidity of pain.Acute pain stimulation information can quickly regulate the activity of dopamine(DA)neurons in the VTA,and persistent chronic pain stimulation can reduce the excitability of DA neurons in the VTA.Anterior IC(AI)and posterior IC(PI)are involved in the formation of pain emotions and the perception of pain information,respectively.IC will undergo plastic changes,and the long-term potentiation(LTP)effect of synaptic transmission will appear in the state of chronic pain.The DA neural pathway from VTA to IC may be directly involved in the transmission and regulation of pain information in humans or animals.The researches on the DA neural pathway of VTA-IC may provide a new target for the clinical treatment of chronic pain.

关 键 词：慢性痛 中脑腹侧被盖区 岛叶 多巴胺 Γ-氨基丁酸 

分 类 号：Q426[生物学—神经生物学]