川芎嗪对脓毒症心肌损伤患者血清和肽素、心型脂肪酸结合蛋白及心脏舒缩功能的影响  

Effect of tetramethylpyrazine injection on serum Copeptin、HFABP and cardiac systolic and diastolic function in patients with sepsis myocardial damage

作　　者：胡娟 曹平 全瑶 何代忠 HU Juan;CAO Ping;QUAN Yao;HE Daizhong(Department of Ultrasound(Bishan Hospital,the First Affiliated Hospital of Chongqing Medical University),Chongqing 402760,China)

机构地区：[1]重庆市璧山区人民医院(重庆医科大学第一附属医院璧山医院)超声医学科,重庆402760 [2]重庆市璧山区人民医院(重庆医科大学第一附属医院璧山医院)重症医学科,重庆402760

出　　处：《中国急救复苏与灾害医学杂志》2020年第11期1292-1295,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：重庆市卫生和计划生育委员会科研计划(编号:2016MSXM180)。

摘　　要：目的观察川芎嗪注射液对脓毒症心肌损伤患者血清和肽素、心型脂肪酸结合蛋白(HFABP)及心脏舒缩功能的影响。方法选取2018年1月-2019年3月重庆市璧山区人民医院收治的脓毒症心肌损伤患者84例,按随机数字表法将患者分为对照组(42例)和川芎嗪治疗组(42例),对照组给予常规治疗,治疗组在常规治疗的基础上加用川芎嗪120mg,每日1次,疗程为7d。于治疗前及治疗后1、3、7d测定血清和肽素、HFABP水平;进行心脏超声检查,测定二尖瓣舒张早期充盈峰速度E峰(E)与舒张晚期充盈峰速度A峰(A)、二尖瓣环舒张早期速度(e')的比值及左心室射血分数(LVEF)。结果两组血清和肽素、HFABP水平治疗后1d均明显高于治疗前,治疗后3、7 d均明显低于治疗前(P<0.05);与对照组比较,川芎嗪治疗组血清和肽素、HFABP在治疗后1、3d明显低于对照组(P<0.05)。两组患者E/e'治疗后1、3d高于治疗前,川芎嗪治疗组E/e'治疗后1、3 d明显低于对照组(P<0.05)。对照组患者LVEF治疗后1、3d低于治疗前,治疗后7 d明显高于治疗前(P<0.05);川芎嗪治疗组治疗后1、3d与治疗前比较差异无统计学意义(P>0.05),治疗后7 d明显高于治疗前(P<0.05);川芎嗪治疗组治疗后各时间点均高于对照组(P<0.05)。结论中药川芎嗪能更好地保护脓毒症心肌损伤患者的心脏功能,降低血清和肽素、HFABP的表达。Objective To explore the effect of tetramethylpyrazine(TMP)on serum copeptin,heart fatty acid binding protein(HFABP)and cardiac systolic,diastolic function cardiac function in patients with sepsis myocardial iniury.Methods Eighty-four patients with sepsis myocardial injury were admitted in People's Hospital of Bishan County from January 2018 to March 2019,and randomLy divided into control group(42 cases)and TMP treatment group(42 cases).Patients in control group were given conventional treatment,while TMP treatment group were given traditional Chinese medicine(TCM)TMP on the basis of base of conventional treatment.TMP 120 mg was added to 250 mL normal saline(NS)for intravenous drip once a day for a therapeutic course of 7 days.Serum copeptin and HFABP levels were measured,And early diastolic filling wave(E),late filling wave(A)and early diastolic velocity of the mitral annulus(e’)and left ventricular ejection fraction(LVEF)were measured by cardiac ultrasound before treatment and on 1,3 and 7 days after treatment.Results The levels of copeptin,HFABP in the two groups were higher than those before treatment after treatment 1rd,and were lower after treatment 3,7rd.Compared with control group,the levels of copeptin,HFABP in the TMP groups were lowerthan those before treatment after treatment l,3rd(P<0.05).Compared with data on the before treatment,E/e’increased on the 1,3rd day in both group(P<0.05).Compared with control group,E/e’is lower on the 1st day and 3rd day in TMP group(P<0.05).Compared with data on the before treatment,LVEF decreased on the 1,3rd day and increased on the 7rd in control group(P<0.05).Compared with control group,E/e’is lower on the 1st day and 3rd day in TMP group(P<0.05).Compared with data on the before treatment,LVEF were no significant difference on the 1,3rd day(P>0.05),and increased on the 7rd in TMP group(P<0.05).Compared with control group,LVEF are higher on the 1,3,7rd day in TMP group(P<0.05).Conclusion TMP can better improve the cardiac function and decrease the level of cop

关 键 词：脓毒症心肌损伤 川芎嗪 和肽素 心型脂肪酸结合蛋白 心脏舒缩功能 

分 类 号：R631[医药卫生—外科学]