针刺联合药物治疗突发性聋的临床随机对照试验Meta分析  

Meta-Analysis of Clinical Randomized Control Study of Acupuncture Combined with drugs in treatment of Sudden Deafness

作　　者：刘义森[1] 查大慧 黄学勤[1] 刘业海[2] 洪飞[1] LIU Yisen;ZHA Dahui;HUANG Xueqin;LIU Yehai;HONG Fei(The Third Clinical College of Anhui Medical University·The Third People's Hospital of HeFei,Department of Otolaryngology,Hefei Anhui Province,230022,China)

机构地区：[1]安徽合肥市第三人民医院耳鼻咽喉科,230022 [2]安徽医科大学第一附属医院耳鼻咽喉头颈外科,合肥

出　　处：《中国中西医结合耳鼻咽喉科杂志》2020年第5期360-365,共6页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的评价针刺联合药物治疗突发性聋(SHL)的疗效,为医疗推广应用起到参考依据。方法计算机检索中国生物医学文献数据库,万方、维普、知网收录的有关针刺联合药物诊治突发性聋的效果分析的文章,检索年限设定在从建库到2020年4月。规范设定纳、排标准,同时参照此标准,进行文献的采取以及资料的提取工作,借助软件Rev Man 5.3开展Meta分析,通过漏斗图体现偏倚性。纳入Meta分析的文献共20篇,均为临床随机对照治疗研究,包含1621个研究对象,比较联合治疗的观察组与单一用药的对照组治疗突发性聋总有效率是否有差异。结果就SHL采取针刺+药物疗法与单一药物疗法的效果展开对比分析,Z=9.49,RR=0.19,95%CI为(0.15,0.23),差异有统计学意义(P<0.001)。说明针刺联合药物相比于单一用药治疗突发性聋,其有效率差异有显著性,有效率明显高于单一药物治疗。结论使用针刺联合药物医治突发性聋疗效显著,值得推广应用。Objective To evaluate the clinical efficacy of acupuncture combined with drug therapy for sudden deafness(SHL),and to provide a basis for the clinical application.Methods Computers were searched for articles on the clinical effects of acupuncture combined with drugs in the treatment of sudden deafness,which were included in the China Knowledge Network,Wanfang,Weipu,and China Biomedical Literature Database.The search period was set from the establishment of the library to April 2020.Meta-analysis was performed using Rev Man 5.3 software based on inclusion and exclusion criteria for inclusion in the literature and extraction of data,and use the funnel chart for bias analysis.A total of 20 articles included in the Meta-analysis were randomized controlled trials,including 1621 subjects.The total effective rate of sudden deafness was compared between the observation group and the single-drug control group.Results The curative effect of the two groups in treating sudden deafness was Z=9.49,RR=0.19,95%CI was(0.15,0.23),the difference was statistically significant(P<0.001).It showed that the effectiveness of acupuncture combined with medicine in treating sudden deafness was significant compared with the effectiveness of traditional medicine treatment.The effectiveness of acupuncture combined with medicine in treating sudden deafness was significantly higher than that of drug treatment.Conclusion The use of acupuncture combined with drugs for the treatment of sudden deafness is significant,and it is worthy of popularization and application in the clinic.

关 键 词：针刺 突发性聋 随机对照试验 META分析 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]