金昌队列人群高血压发病风险及影响因素  

The risk and influencing factors of hypertension in Jinchang cohort

作　　者：缪茜 郑山[1] 罗妍 王敏珍[1] 朱文芝 石琴 李海燕[2] 白亚娜[1] MIAO Qian;ZHENG Shan;LUO Yan;WANG Ming-zhen;ZHU Wen-zhi;SHI Qin;LI Hai-yan;BAI Ya-na(Institute of Epidemiology and Health Statistics,School of Public Health,Lanzhou University,Lanzhou Gansu 730000,China;不详)

机构地区：[1]兰州大学公共卫生学院流行病与卫生统计研究所,甘肃兰州730000 [2]金川集团股份有限公司职工医院内科

出　　处：《中华高血压杂志》2020年第10期953-959,共7页Chinese Journal of Hypertension

基　　金：兰州大学中央高校基本科研业务费专项资金(lzujbky-2018-69,lzujbky-2018-66)。

摘　　要：目的探讨金昌队列人群高血压发病风险及影响因素。方法采用前瞻性队列研究方法,依托金昌队列平台,收集2011-2015年职工22826人的基线及随访信息,计算队列人群高血压发病密度,采用Cox比例风险模型分析影响因素。结果研究对象平均随访2.2年,人群高血压发病密度为56.31/千人年;多因素Cox回归分析发现,人群高血压发病主要危险因素包括年龄≥40岁、饮酒、高盐膳食、糖尿病史、高血压家族史、超重及肥胖、基线收缩压≥110、舒张压≥75 mm Hg,而教育程度是保护性因素;1级高血压发病与年龄、饮酒、糖尿病史、高血压家族史、基线血压水平有关,2、3级高血压发病与高盐膳食、高血压家族史、超重及肥胖、基线血压水平有关。结论金昌队列人群高血压发病风险较高。年龄、不良生活行为方式、糖尿病史、高血压家族史、体质量指数(BMI)、基线血压水平与高血压发病密切相关。1、2、3级高血压发病的危险因素存在差异。Objective To investigate the incidence and influencing factors of hypertension in Jinchang cohort.Methods A prospective cohort study was conducted to collect the baseline and follow-up information of 22826 employees from 2011 to 2015 based on the Jinchang cohort platform.The incidence of hypertension in the cohort was caculated and the influencing factors was analyzed by Cox proportional risk model.Results(1)The subjects were followed up for an average of 2.2 years,and the incidence density of hypertension was 56.31/1000 person-years;(2)Multivariate Cox regression results showed that the main risk factors for hypertension in the population included age≥40 years,alcohol consumption,high-salt diet,history of diabetes,family history of hypertension,overweight and obesity,baseline systolic blood pressure≥110 mm Hg and diastolic blood pressure≥75 mm Hg,and education level(in middle school,high school and above)was a protective factor;(3)The incidence of grade 1 hypertension was related to age,drinking,history of diabetes,family history of hypertension and baseline blood pressure levels,and the incidence of grade 2 and 3 hypertension was related to high-salt diet,family history of hypertension,overweight or obesity and baseline blood pressure levels.Conclusions The Jinchang cohort has a higher risk of hypertension.Age,unhealthy lifestyle,history of diabetes,family history of hypertension,body mass index(BMI)and baseline blood pressure are strongly associated with the onset of hypertension.There are differences in the risk factors for the occurrence of grade 1,2 and 3 hypertension.

关 键 词：高血压 发病密度 影响因素 临床分级 前瞻性队列研究 

分 类 号：R544.1[医药卫生—心血管疾病]