补肾活血方药联合低分子肝素干预早期复发性流产血栓前状态的临床研究  

Study the effect of kidney-tonifying and blood-activating formula combined with low-molecular-weight heparin on pre-thrombotic state of early recurrent abortion

作　　者：陈春 尤爱娟 徐妃 曹万英 陈春丽 梁金梅 邱丽珊 CHEN Chun;YOU Ai-juan;XU Fei(Yangchun Hospital of Traditional Chinese Medicine,Yangchun 529600,China)

机构地区：[1]阳春市中医院,529600

出　　处：《中国实用医药》2020年第31期147-149,共3页China Practical Medicine

基　　金：阳卫函[2018]322号(项目编号:阳卫计2018034)。

摘　　要：目的研究补肾活血方药联合低分子肝素干预对早期复发性流产血栓前状态的影响。方法 80例复发性流产、经筛查存在血栓前状态的患者,随机分为对照组和观察组,各40例。对照组以低分子肝素钙进行皮下注射治疗;观察组在对照组基础上联合补肾活血方进行治疗。观察比较两组患者治疗效果,血栓前状态标志物变化情况及孕12周存活率。结果观察组治疗后总有效率为90.0%,高于对照组的67.5%,差异有统计学意义(P<0.05)。治疗后,观察组纤维蛋白原(FIB)、D-二聚体(D-D)指标水平均低于治疗前,且观察组FIB(2.2±0.3)g/L、D-D(165.2±50.0)μg/L均低于对照组的(3.4±0.4)g/L、(252.5±43.2)μg/L,差异有统计学意义(P<0.05)。观察组孕12周存活率90.0%高于对照组的67.5%,差异有统计学意义(χ2=6.050, P=0.014<0.05)。结论采用补肾活血方药联合低分子肝素对早期复发性流产血栓前状态患者实施治疗,效果显著,可改善凝血、纤溶功能,提升胚胎存活率。Objective To study the effect of kidney-tonifying and blood-activating formula combined with low-molecular-weight heparin on pre-thrombotic state of early recurrent abortion. Methods A total of 80 patients with pre-thrombotic state of early recurrent abortion were randomly divided into control group and observation group, with 40 cases in each group. The control group was treated by subcutaneous injection of lowmolecular-weight heparin calcium, and the observation group was treated with kidney-tonifying and bloodactivating formula on the basis of the control group. The therapeutic effect, changes of prethrombotic state markers and survival rate at 12 weeks of gestation were observed between the two groups. Results The total effective rate of the observation group was 90.0%, which was higher than 67.5% of the control group, and the difference was statistically significant(P<0.05). After treatment, fibrinogen(FIB), D-Dimer(D-D) of the observation group were lower than those before treatment, and FIB(2.2±0.3) g/L and D-D(165.2±50.0) μg/L of the observation group were lower than(3.4±0.4) g/L and(252.5±43.2) μg/L of the control group, and the difference was statistically significant(P<0.05). The survival rate at 12 weeks of gestation 90.0% of the observation group was higher than 67.5% of the control group, and the difference was statistically significant(χ~2=6.050, P=0.014<0.05). Conclusion Kidney-tonifying and blood-activating formula combined with low-molecular-weight heparin shows remarkable effect on patients with pre-thrombotic state of early recurrent abortion, and it can improve coagulation and fibrinolysis function, and improve embryo survival rate.

关 键 词：补肾活血方药 早期复发性流产 血栓前状态 低分子肝素 凝血功能 胚胎存活率 

分 类 号：R714.21[医药卫生—妇产科学]